Cytokines Flashcards
Secreted by macrophages?
IL-1, 6, 8, 12, TNF-a
Secreted by all T-cells?
IL-2, 3
Secreted by Th1 cells?
IFN-g
Secreted by Th2 cells?
IL-4, 5, 10
Endogenous pyrogen, acts on anterior hypothalamus to increase set point?
IL-1 and IL-6
Stimulates growth of helper, cytotoxic, and T-reg cells?
IL-2
Stimulates bone marrow stem cells?
IL-3 (acts like GM-CSF)
Activates Th1 and NK cells and it also secreted by B-cells?
IL-12
Mediates septic shock?
TNF-a
Activates endothelium to express adhesion molecules?
IL-1
Major chemotactic factor for neutrophils?
IL-8
Stimulates production of APPs by liver?
IL-6
Stimulates macrophages?
IFN-g
Inhibits Th2 cells?
IFN-g
Enhances class switching to IgE and IgG?
IL-4
Enhances class switching to IgA?
IL-5
Inhibits Th1 cells?
IL-10
Stimulates eosinophil production?
IL-5
Place uninfected cells in antiviral state?
Interferons
MOA of interferons?
Induce production of ribonuclease that inhibits viral protein synthesis by degrading viral mRNA
Inhibits viral protein synthesis?
IFN-a and IFN-B
Increases MHC I and II expression and Ag presentation in all cells?
IFN-g
Activates Th2 cells?
IL-4 and IL-10
Promotes B-cell growth?
IL-4
Promotes B-cell differentiation?
IL-5
