Cytokines

Question 1

What does IL-3 cause?

Answer 1

Stimulates hematopoiesis

Question 2

What does IL-4 cause?

Answer 2

Stimulates isotype switching of B cells to IgE

Question 3

What does IL-5 cause?

Answer 3

Eosinophil activation

Question 4

What does IL-6 cause?

Answer 4

Liver: Synthesis of acute phase proteins

Question 5

What does IL-11 cause?

Answer 5

Production of platelets

Question 6

What does IL-12 cause?

Answer 6

Cause NK cells and T cells to produce INF-gamma

Question 7

What does IL-13 cause?

Answer 7

B cell: Isotype switching to IgE

Epithelial cells: increase mucus production

Question 8

What does IL-17 cause?

Answer 8

Epithelial cells: G-CSF and GM-CSF production

GM-CSF (granulocyte-monocyte colony stimulating factor)

Question 9

What does IL-21 cause?

Answer 9

NK maturation

Question 10

What does IL-25 cause?

Answer 10

Stimulates T cell production of lL-5 and IL-13

Question 11

What does IFN alpha and beta cause?

Answer 11

Increase in MHC class I expression

NK activation

Question 12

What does IFN-gamma cause?

Answer 12

B cell: isotype switching to IgG

Increase in expression of MHC class I and II cells

Increase in Ag presentation to T cells

Question 13

What does TNF cause?

Answer 13

Inflammation
Fever
Activate Neutrophils

Question 14

What does TGF-beta causes?

Answer 14

Inhibits macrophage activation

Stimulates IgA production

Question 15

What does IL-18 cause?

Answer 15

Stimulates NK and T cells to produce INF-gamma

Stimulates monocytes to express GM-CSF and TNF