Cytokines

Question 1

You’re doing amazing sweetie

Answer 1

:) lol it made me add another card

Question 2

What does CCL19 do?

Answer 2

T cell and dendritic cell migration into the HEV of the lymph node

Question 3

What does the CCL21 do?

Answer 3

T cell and dendritic cell migration into the HEV of the lymph node

Question 4

What does IL-8 do?

Answer 4

Neutrophil recruitment in the blood vessel
-cell chemotaxis

SOOO as the neutrophil is rolling, it is looking for these IL-8’s that are one the endothelial cells

Question 5

What is the function of CCL2? (MCP-1)

Answer 5

Transmigration of monocytes

Question 6

What is the role of CXCL10?

Answer 6

To bring cells into the tissues; it is produced at the sites of infection

IN PERIPHERAL TISSUES

Question 7

What is the role of CCL4?

Answer 7

Activation of integrins and chemokinesis

IN PERIPHERAL TISSUES

Question 8

What is the role of CXCL1?

Answer 8

Neutrophil recruitment

Question 9

What is the role of CD44?

Answer 9

mobilization of effector T cells; can also mediate rolling interactions with endothelial cells that express HA

Question 10

What does the binding of CD44 and HA result in?

Answer 10

GPCR-dependent “inside out” upregulation of VLA-4-VCAM binding

Question 11

What is the role of CXCL12?

Answer 11

Homing chemokine

Question 12

What is the role of CXCL13? and who recognizes her?

Answer 12

Aids in B cell migration into the follicles, is recognized by CXCR5

Question 13

What is the role of NFkB?

Answer 13

pro-inflammatory genes; remember the TLR4 ish

Question 14

What does IFN-alpha and beta do?

Answer 14

resistance to viral infection

Question 15

What does IFN gamma do?

Answer 15

macrophage activation

Question 16

What does IL-12 do?

Answer 16

stimulates IFN gamma production by NK and T cells

Question 17

What does IL-15 do?

Answer 17

Proliferation of NK cells

Question 18

What is the role of IL-1?

Answer 18

pro inflammatory cytokine that regulates the expression of adhesive molecules on endothelial cells

-activates the endothelium to allow the selections to act

Question 19

Which cytokine causes fever?

Answer 19

IL-1

Question 20

What is TNF-alpha

Answer 20

pro inflammatory cytokine that regulates the expression of adhesive molecules on endothelial cells
-stimulates and activates macrophages

Question 21

What do IL-1beta and IL-18 do?

Answer 21

drive inflammation

Question 22

What does IL-6 do?

Answer 22

Mediator of inflammation

also activates the classical complement pathway

Question 23

What are the proliferation cytokines?

Answer 23

IL-2, IL-4, IL-5

Question 24

Which antibodies does IL-4 induce?

Answer 24

IgG1 and IgG2a

Question 25

Which antibodies does IL-4 inhibit?

Answer 25

IgM, IgG3, IgG2

Question 26

Which antibody does IL-5 augment production of?

Answer 26

IgA

Question 27

What antibodies does IFN-gamma inhibit?

Answer 27

IgM, IgG1, IgE

Question 28

What antibodies does IFN-gamma induce?

Answer 28

IgG3, IgG2a

Question 29

What antibodies does TGF-beta inhibit?

Answer 29

IgM, IgG3

Question 30

What antibodies does TGF-beta induce?

Answer 30

IgG2b, IgA

Question 31

What does IL-2 do?

Answer 31

Controls clonal expansion of T cells

Question 32

What are all of the things that are able to secrete IFN-gamma

Answer 32

Th1 cells, NK cells, helper T cells

Question 33

What does IL-4?

Answer 33

B cell proliferation

Question 34

Who is able to secrete IL-4?

Answer 34

Th2 cells to help B cell proliferation