Cytokines

Question 1

IL-1

Answer 1

secreted by macrophages; FEVER (endogenous pyrogen)

Question 2

IL-2

Answer 2

secreted by Th1 cells; stimulates growth of T cells (CD8+ activation)

Question 3

IL-3

Answer 3

secreted by T cells; stimulates bone marrow growth

Question 4

IL-4

Answer 4

secreted by Th2 cells; promotes B cell growth and class switching to IgE; induces differentiation of T cells –> Th2 cells (humoral immunity)

Question 5

IL-5

Answer 5

secreted by Th2 cells; promotes B cell growth and class switching to IgA; stimulates production and activation of eosinophils

Question 6

IL-6

Answer 6

secreted by macrophages and Th cells; stimulates production of acute phase proteins

Question 7

IL-8

Answer 7

secreted by macrophages; promotes chemotaxis for neutrophils

Question 8

IL-10

Answer 8

secreted by Th2 cells and regulatory T cells; atTENuates inflammatory response

Question 9

IL-12

Answer 9

secreted by macrophages; induces differentiation of T cells –> Th1 cells (cell mediated immunity); activates NK cells

Question 10

TNF-alpha

Answer 10

secreted by macrophages; mediates septic shock, activates endothelium, leukocytes recruitment, vascular leak

Question 11

IFN-gamma

Answer 11

secreted by Th1 cells; activates macrophages and has anti-viral and anti-tumor properties (activates Th1 and inhibits Th2)

Question 12

Which cytokines are helpful in formation/maintenance of granulomas?

Answer 12

IFN-gamma activates macrophages; TNF-alpha induces and maintains; on anti-TNF alpha meds (infliximab) can lead to disseminated TB