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STEP1 > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Terbinafine - MOA

A

Inhibits fungal squalene epoxidase

USed for dermatophyte infections

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2
Q

Nystatin - MOA

A

Binds ergosterol in fungal cell membranes, forming pores

Used for Candida - topical use only

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3
Q

Amphotericin B - MOA

A

Binds ergosterol in fungal cell membranes, forming pores

Bactericidal

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4
Q

Echinocandins - MOA

A

Inhibit synthesis of fungal cell WALL by blocking synthesis of beta-1,3-glucan

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5
Q

Azoles - MOA

A

Inhibition of ergosterol synthesis from lanosterol (inhibition of fungal CYP450 - causes drug-drug interactions)

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6
Q

Azoles - AEs

A 
CYP450 inhibition (worst w ketoconazole)
Antiandrogenic effects w ketoconazole
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7
Q

Flucytosine - AEs

A

Bone marrow suppression

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8
Q

Griseofulvin - MOA

A

Inhibits squalene epoxidase

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9
Q

Griseofulvin -AEs

A

Hepatotoxicity, headache , rash, granulocytopenia

CYP inducer

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10
Q

Griseofulvin -AEs

A

Hepatotoxicity, headache , rash, granulocytopenia

CYP inducer

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11
Q

Echinocandins - AEs

A

GI upset and flushing

generally well tolerated

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STEP1 (11 decks)

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