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Week 1 > Cytokines > Flashcards

Cytokines Flashcards

2
Q

Cytokines secreted by macrophages

A

IL-1, IL-6, IL-8, IL-12, TNF-alpha

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3
Q

Cytokines secreted by Th2 cells

A

IL-4, IL-5, IL-6, IL-10, IL-13

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4
Q

Cytokines secreted by T cells

A

IL-2, IL-3

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5
Q

Cytokines secreted by Regulatory T cells

A

IL-10, TGF-beta

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6
Q

Cytokines secreted by B cells

A

IL-12

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7
Q

Cytokines secreted by Th1 cells

A

IFN-gamma

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8
Q

Endogenous pyrogens; cause fever

A

IL-1, IL-6

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9
Q

Causes acute inflammation

A

IL-1

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10
Q

Activates endothelium to express adhesion molecules

A

IL-1, TNF-alpha

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11
Q

Induces chemokine secretion to recruit leukocytes

A

IL-1, TNF-alpha

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12
Q

Simulates production of acute-phase proteins

A

IL-6

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13
Q

Major chemotactic factor for neutrophils

A

IL-8

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14
Q

Induces differentiation of T cells into Th1 cells

A

IL-12

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15
Q

Activates NK cells

A

IL-2, IL-12, IFN-alpha, IFN-beta, IFN-gamma

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16
Q

Mediates septic shock

A

TNF-alpha

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17
Q

Causes vascular leak

A

TNF-alpha

18
Q

Stimulates growth of helper, cytotoxic, and regulatory T cells

A

IL-2

19
Q

Supports growth and differentiation of bone marrow stem cells

A

IL-3

20
Q

Functions like GM-CSF

A

IL-3

21
Q

Activates macrophages and Th1 cells

A

IFN-gamma

22
Q

Suppresses Th2 cells

A

IFN-gamma

23
Q

Has antiviral and antitumor properties

A

IFN-gamma

24
Q

Induces differentiation into Th2 cells

A

IL-4

25
Q

Promotes growth of B cells

A

IL-4

26
Q

Enhances class switching to IgE and IgG

A

IL-4

27
Q

Promotes differentiation of B cells

A

IL-5

28
Q

Enhances class switching to IgA

A

IL-5

29
Q

Stimulates the growth and differentiation of eosinophils

A

IL-5

30
Q

Modulates inflammatory response

A

IL-10

31
Q

Inhibits actions of activated T cells and Th1

A

IL-10

32
Q

Involved in inhibiting inflammation

A

TGF-beta

33
Q

Place uninfected cells in an antiviral state

A

Interferons

34
Q

Induce the production of a ribonuclease that inhibits viral protein synthesis by degrading viral mRNA

A

Interferons

35
Q

Inhibit viral protein synthesis

A

INF-alpha, INF-beta

36
Q

Increases MHC I and II expression and antigen presentation in all cells

A

IFN-gamma

37
Q

Activates NK cells to kill virus-infected cells

A

Interferons

Week 1 (8 decks)

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