Cytokines Flashcards
Cytokines secreted by macrophages
IL-1, IL-6, IL-8, IL-12, TNF-alpha
Cytokines secreted by Th2 cells
IL-4, IL-5, IL-6, IL-10, IL-13
Cytokines secreted by T cells
IL-2, IL-3
Cytokines secreted by Regulatory T cells
IL-10, TGF-beta
Cytokines secreted by B cells
IL-12
Cytokines secreted by Th1 cells
IFN-gamma
Endogenous pyrogens; cause fever
IL-1, IL-6
Causes acute inflammation
IL-1
Activates endothelium to express adhesion molecules
IL-1, TNF-alpha
Induces chemokine secretion to recruit leukocytes
IL-1, TNF-alpha
Simulates production of acute-phase proteins
IL-6
Major chemotactic factor for neutrophils
IL-8
Induces differentiation of T cells into Th1 cells
IL-12
Activates NK cells
IL-2, IL-12, IFN-alpha, IFN-beta, IFN-gamma
Mediates septic shock
TNF-alpha
Causes vascular leak
TNF-alpha
Stimulates growth of helper, cytotoxic, and regulatory T cells
IL-2
Supports growth and differentiation of bone marrow stem cells
IL-3
Functions like GM-CSF
IL-3
Activates macrophages and Th1 cells
IFN-gamma
Suppresses Th2 cells
IFN-gamma
Has antiviral and antitumor properties
IFN-gamma
Induces differentiation into Th2 cells
IL-4
Promotes growth of B cells
IL-4
Enhances class switching to IgE and IgG
IL-4
Promotes differentiation of B cells
IL-5
Enhances class switching to IgA
IL-5
Stimulates the growth and differentiation of eosinophils
IL-5
Modulates inflammatory response
IL-10
Inhibits actions of activated T cells and Th1
IL-10
Involved in inhibiting inflammation
TGF-beta
Place uninfected cells in an antiviral state
Interferons
Induce the production of a ribonuclease that inhibits viral protein synthesis by degrading viral mRNA
Interferons
Inhibit viral protein synthesis
INF-alpha, INF-beta
Increases MHC I and II expression and antigen presentation in all cells
IFN-gamma
Activates NK cells to kill virus-infected cells
Interferons
