Blood Transfusion Proteins Flashcards
Pathogenesis of Allergic Reaction
Type I hypersensitivity against plasma proteins in transfused blood
Clinical Presentation of Allergic Reaction
Urticaria, pruritis, wheezing, fever
Treatment for Allergic Reaction
Antihistamines
Pathogenesis of Anaphylactic Reaction
Severe; IgA deficient individuals must receive blood products that lack IgA
Clinical Presentation of Anaphylactic Reaction
Dyspnea, bronchospasm, hypotension, respiratory arrest, shock
Pathogenesis of Febrile Nonhemolytic Transfusion Reaction (FNHTR)
Type II hypersensitivity; host Ab against donor HLA Ag and leukocytes
Clinical Presentation of Febrile Nonhemolytic Transfusion Reaction (FNHTR)
Fever, headache, chills, flushing
Pathogenesis of Acute Hemolytic Transfusion Reaction (HTR)
Type II hypersensitivity reaction; intravascular hemolysis (ABO incompatibility) or extravascular hemolysis (host Ab reaction against foreign Ag on donor RBCs)
Clinical Presentation of Acute Hemolytic Transfusion Reaction (HTR)
Fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinemia (intravascular), jaundice (extravascular hemolysis)
Type I hypersensitivity
Allergic reaction
Type II hypersensitivity
Febrile Nonhemolytic Transfusion Reaction (FNHTR), Acute Hemolytic Transfusion Reaction (HTR)