Blood Transfusion Proteins Flashcards

2
Q

Pathogenesis of Allergic Reaction

A

Type I hypersensitivity against plasma proteins in transfused blood

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3
Q

Clinical Presentation of Allergic Reaction

A

Urticaria, pruritis, wheezing, fever

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4
Q

Treatment for Allergic Reaction

A

Antihistamines

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5
Q

Pathogenesis of Anaphylactic Reaction

A

Severe; IgA deficient individuals must receive blood products that lack IgA

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6
Q

Clinical Presentation of Anaphylactic Reaction

A

Dyspnea, bronchospasm, hypotension, respiratory arrest, shock

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7
Q

Pathogenesis of Febrile Nonhemolytic Transfusion Reaction (FNHTR)

A

Type II hypersensitivity; host Ab against donor HLA Ag and leukocytes

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8
Q

Clinical Presentation of Febrile Nonhemolytic Transfusion Reaction (FNHTR)

A

Fever, headache, chills, flushing

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9
Q

Pathogenesis of Acute Hemolytic Transfusion Reaction (HTR)

A

Type II hypersensitivity reaction; intravascular hemolysis (ABO incompatibility) or extravascular hemolysis (host Ab reaction against foreign Ag on donor RBCs)

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10
Q

Clinical Presentation of Acute Hemolytic Transfusion Reaction (HTR)

A

Fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinemia (intravascular), jaundice (extravascular hemolysis)

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11
Q

Type I hypersensitivity

A

Allergic reaction

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12
Q

Type II hypersensitivity

A

Febrile Nonhemolytic Transfusion Reaction (FNHTR), Acute Hemolytic Transfusion Reaction (HTR)

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