Complement

Question 2

MAC defends against what type of bacteria?

Answer 2

Gram negative

Question 3

Activation of classic pathway

Answer 3

IgG or IgM

Question 4

Activation of alternative pathway

Answer 4

Microbe surface molecules

Question 5

Activation of lectin pathway

Answer 5

Mannose or other sugars on microbe surface

Question 6

Function of C3b

Answer 6

Opsonization, clear immune complexes

Question 7

Function of C3a

Answer 7

Anaphylaxis

Question 8

Function of C5a

Answer 8

Anaphylaxis, neutrophil chemotaxis

Question 9

Function of C5b-9

Answer 9

Cytolysis by MAC

Question 10

Primary opsonins in bacterial defense

Answer 10

C3b and IgG

Question 11

Inhibitors

Answer 11

Decay-accelerating factor (DAF) and C1 esterase inhibitor

Question 12

C1 esterase inhibitor deficiency

Answer 12

Hereditary angioedema

Question 13

What is contraindicated in C1 esterase inhibitor deficiency?

Answer 13

ACE-Inhibitors

Question 14

C3 deficiency manifestations

Answer 14

Severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions

Question 15

C5-C9 deficiencies

Answer 15

Recurrent Neisseria bacteremia

Question 16

DAF (GPI anchored enzyme) deficiency

Answer 16

Complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH)