Cytokines

Question 1

Interferon-γ

Answer 1

key mediator of cell-mediated immune responses

Question 2

Interleukin-1

Answer 2

proinflammatory mediator and a Th2 cell stimulator

Question 3

Interleukin-2

Answer 3

upregulates cell survival genes

increases energy metabolism

promotes T cell division

Question 4

Interleukin-4

Answer 4

stimulates the growth and differentiation of B cells

activates mast cells

Question 5

Interleukin-6

Answer 5

needed for final differentiation of B cells into plasma cells

Question 6

Interleukin-8

Answer 6

attracts and activates neutrophils

Question 7

Interleukin-12

Answer 7

the major activator of Th1 cells and NK cells

Question 8

Interleukin-13

Answer 8

stimulates B cell growth

suppresses macrophages

Question 9

Interleukin-21

Answer 9

regulates NK, B, and T cell function

Question 10

Interleukin-22

Answer 10

promotes innate immunity in cells of the skin, digestive and respiratory systems

Question 11

Interleukin-23

Answer 11

stimulates Th17 cells to secrete IL-17 and IL-22

Question 12

Transforming growth factor-β (TGF-β)

Answer 12

regulate cell division, enhance the deposition of extracellular matrix proteins, and are immunosuppressive

Question 13

Tumor necrosis factor-α (TNF-α)

Answer 13

central inducer of inflammation

Question 14

CCL3

aka ___________________

Answer 14

chemokine thatrecruitsand activatespolymorphonuclear leukocytes

(aka macrophage inflammatory protein)

Question 15

Interleukin-17

Answer 15

stimulate macrophages and endothelial cells to secrete proinflammatory cytokines and chemokines

Question 16

Interleukin-5

Answer 16

stimulates B cell growth

mobilizes and activates eosinophils

Question 17

Interleukin-9

Answer 17

T cell growth factor

Question 18

Interleukin-10

Answer 18

Inhibits Th1 cells

suppresses macrophages