Clusters of Differentiation (CD)

Question 1

CD3

Answer 1

signal transducing molecules of the TCR found only on T cells

Question 2

CD23

Answer 2

receptor for IgE

regulates B cell responses by binding to CD21

Question 3

CD28

Answer 3

binds to CD80 on APC and CD86 on B cells

Eight-fold activation of T cells

Question 4

CD32

Answer 4

IgG receptor

Question 5

CD40

Answer 5

binds to CD154 on activated helper T cells

essential for a successful antibody response

Question 6

CD44

Answer 6

receptor for hyaluronic acid

mediates binding of cells to high endothelial venules

Question 7

CD49

Answer 7

integrin α chain associated with CD29 β chain

binds to extracellular matrix protein

Question 8

CD54 aka ICAM-1

Answer 8

on vascular endothelial cells

binds to CD11/CD18 integrins

Question 9

CD80

Answer 9

APC receptor for CD28 and CD152

crucial to T cell communication with antigen-presenting cells

Question 10

CD86

Answer 10

B cell receptor for CD28 and CD152

co-stimulatory with CD80

Question 11

CD95

Answer 11

signaling component of cell death pathway

Question 12

CD152

Answer 12

binds CD80/86 to suppress T cell activation

Question 13

CD154

Answer 13

cross-links with CD40 on antigen presenting cells to activate the T cell