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Perio > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL 1

A 
peliomorphic
Osteoclast activity
CD4 activation
B cell maturation
PMN and macrophage chemotaxis
Increase activity of:
        * NK Cells
        * Fibroblasts
        * PGE2 and bone resorption
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2
Q

IL 1 is secreted by?

A 
Monocytes
macrophages
B cells
Fibroblasts
PMNs
epithelial cells
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3
Q

Where can IL 1 be found?

A

Gingival tissues
GCF
DECREASES AFTER PERIODONTAL TREATMENT

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4
Q

IL 2

A

T CELL GROWTH FACTOR
general role in immune response
induces NK function
INCREASES IN PERIODONTAL TISSUES IN PERIODONITITS

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5
Q

IL 2 is secreted by?

A

CD4 and NK cells

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6
Q

IL 3

A

hematopoietic cell growth and proliferation
stimulate mast cell growth
histamine release

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7
Q

IL 3 is secreted by?

A

activated CD4 cells

NK cells

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8
Q

IL 4

A

B CELL GROWTH FACTOR
T cell growth
Macrophage function
mast cell growth

INCREASES IN PERIODONTAL TISSUES IN PERIODONTITIS

** B CELL IgE SYNTHESIS ***

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9
Q

IL 4 is secreted by?

A

CD4 cells

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10
Q

IL 5

A

B cell proliferation

** IgA PRODUCTION **

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11
Q

IL 5 is secreted by?

A

CD4 cells

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12
Q

IL 6

A

plasma cell production
activates CD4 cells via IL 1
INCREASES IN SITES OF GINGIVAL INFLAMMATION
bone resorption

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13
Q

IL 6 is secreted by?

A 
CD4
macrophages
monocytes
fibroblasts
endothelial cells
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14
Q

IL 7

A

T cell proliferation

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15
Q

IL 7 is secreted by?

A

Bone marrow stream cells

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16
Q

IL 8

A

chemotactic for PMNs
increases PMN adherence to endothelial cells
PRESENT IN HIGH LEVELS IN PERIO LESIONS ASSOCIATED WITH JE AND MACROPHAGES
high in disease

17
Q

IL 8 is secreted by?

A

macrophages in response to TNF and IL1

18
Q

IL 9

A

Proliferation if CD4 cells in absence of APC

Mast cell growth

19
Q

IL 9 is secreted by?

A

CD4 cells

20
Q

IL 10

A

Inhibits antigen presenting capacity of monocytes

21
Q

IL 10 is secreted by?

A

CD4 cell – help regulate response

22
Q

Interferon

A 
Glycoproteins
Antiviral activity
Enhances 
      macrophage activity
      T cell
       NK cell
BONE RESORPTION -- inhibits proliferation of osteoblasts
23
Q

TNF

A

Activate osteoclasts – bone resorption

TNF alpha –> increases PMN adherence to endothelial cells

24
Q

TNF alpha

A

produced by macrophages in stimulation by LPS

increases PMN phagocytosis and chemotaxis

25
Q

TNF beta

A

cytotoxic for fibroblasts

Plaque antigens – favor generation of TNF beta

26
Q

What does arachidonic acid metabolites do

A

Increase vasopermeability
(Redness, edema)
Induced of MMP secretion
Osteoclasts activation

2-3 fold increase GINGIVITIS
5-6 fold increase PERIODONTITIS

27
Q

Levels of PGE2 in GCF is used to predict

A

Predict Attachment loss

High GCF - PGE2 high risk pts

28
Q

Corticotropan releasing factor –CNS NEUROPEPTIDES

A

Depresses lymphocyte function
Impair neutrophils function
Up regulates the release of IL 1 an TNF
Increase inflammation

Perio (8 decks)

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