Cytokines Flashcards
Which cells produce IL-1
Macrophage, endothelium, epithelium
What is the purpose of IL-1
Fever, synthesis of acute phase proteins
Which cells produce IL-6
Macrophages, endothelium, epithelium
What is the activity of IL-6
Fever, acute phase proteins, and b-cell proliferation of Ab producing cells
Which cells produce TNF-alpha
Macrophages, Tcells (Th1 cells)
What is the activity of TNF-alpha
fever, synthesis of acute phase proteins, killing of tumor cells, muscle/fat catabolism
Which cells produce IL-8
Macrophages, fibroblasts, endothelial cells
What is the activity of IL-8
neutrophil chemoattractant and activation, endothelial cell activation
Which cells produce IL-12
Macrophages
What is the activity of IL-12
Promote Th1 pathway, NK cell activation and IFN-gamma synthesis
Which cells produce IL-10
Macrophages, Th2 cells, Tregs
What is the activity of IL-10
Promotes Th2 pathway, inhibits Th1, inhibits macrophage proinflammatory cytokine release, increases apoptotic death of neutrophils
Which cells produce IL-2
Th cells (naive and Th1)
What is the activity of IL-2
Tcell growth factor, enhanced NK cell activity, induction of bcell Ig production (+/-)
Which cells produce IFN gamma
Th1 cells, CD8 cells, NK cells
What is the activity of IFN gamma
Macrophage activation, antiviral, NK cell activation, increased expression of class I and class II MHC, inhibits Th2 pathway, increases Th1 pathway, promotes class switching B cells to IgG2 while inhibiting IgE
Which cells produce IL-4
Th2 cells
What is the activity of IL-4
Induce b cell proliferation and differentiation, IgE production, Promotes Th2/inhibit Th1, mast cell and basophil activation, mucus production by goblet cells
Which cells produce IL-5
Th2 cells
What is the activity of IL-5
Eosinophil differentiation and activation
Which cells produce IL-13
Th2 cells
What is the activity of IL-13
Bcell growth and differentiation, inhibits Th1 cells and macorphage inflammatory cytokines, ASSOCIATED WITH ASTHMA/ALLERGY
Which cells produce IL-17
Th17 cells
What is the activity of IL-17
Neutrophil recruitment, stimulates cytokine/chemokine production by fibroblasts and epithelial cells, dendritic cells induce Th17 cells from CD4 cells with high levels of TGF-beta, IL-23, and IL-6 during activation
Which cells produce TGF-beta
Th cells, Tregs
What is the activity of TGF-beta
inhibits much of innate immunity, anti-inflammatory, recruits macrophages promoting cleanup, promotes sIgA
Which cells produce IFN-alpha/beta
Induced by virally infected cells GOOD NEIGHBOR CYTOKINE
What is the activity of IFN-alpha/beta
Antiviral, increased MHC class I expression, NK cell activation, macrophage activation
Which cell type is stimulated by SCF, IL-3, IL-1 during hematopoesis
Pluripotent stem cell
Which cell type is stimulated by IL-7 during hematopoesis
Precursor T and B cells
Which cell type is stimulated by GM-CSF during hematopoesis
Myeloid stem cell (gives rise to erythrocyte, neutrophil, macrophage, eosinophil, basophil, platelets)
Which cell type is stimulated by IL-4 during hematopoesis
Basophil
Which cell type is stimulated by IL-5 during hematopoesis
Eosinophils
Which cell type is stimulated by M-CSF during hematopoesis
Monocyte -> Macrophage
Which cell type is stimulated by G-CSF during hematopoesis
Neutrophil
Which cell type is stimulated by EPO during hematopoesis
Erythrocyte
