Cytokines

Question 1

Which cells produce IL-1

Answer 1

Macrophage, endothelium, epithelium

Question 2

What is the purpose of IL-1

Answer 2

Fever, synthesis of acute phase proteins

Question 3

Which cells produce IL-6

Answer 3

Macrophages, endothelium, epithelium

Question 4

What is the activity of IL-6

Answer 4

Fever, acute phase proteins, and b-cell proliferation of Ab producing cells

Question 5

Which cells produce TNF-alpha

Answer 5

Macrophages, Tcells (Th1 cells)

Question 6

What is the activity of TNF-alpha

Answer 6

fever, synthesis of acute phase proteins, killing of tumor cells, muscle/fat catabolism

Question 7

Which cells produce IL-8

Answer 7

Macrophages, fibroblasts, endothelial cells

Question 8

What is the activity of IL-8

Answer 8

neutrophil chemoattractant and activation, endothelial cell activation

Question 9

Which cells produce IL-12

Answer 9

Macrophages

Question 10

What is the activity of IL-12

Answer 10

Promote Th1 pathway, NK cell activation and IFN-gamma synthesis

Question 11

Which cells produce IL-10

Answer 11

Macrophages, Th2 cells, Tregs

Question 12

What is the activity of IL-10

Answer 12

Promotes Th2 pathway, inhibits Th1, inhibits macrophage proinflammatory cytokine release, increases apoptotic death of neutrophils

Question 13

Which cells produce IL-2

Answer 13

Th cells (naive and Th1)

Question 14

What is the activity of IL-2

Answer 14

Tcell growth factor, enhanced NK cell activity, induction of bcell Ig production (+/-)

Question 15

Which cells produce IFN gamma

Answer 15

Th1 cells, CD8 cells, NK cells

Question 16

What is the activity of IFN gamma

Answer 16

Macrophage activation, antiviral, NK cell activation, increased expression of class I and class II MHC, inhibits Th2 pathway, increases Th1 pathway, promotes class switching B cells to IgG2 while inhibiting IgE

Question 17

Which cells produce IL-4

Answer 17

Th2 cells

Question 18

What is the activity of IL-4

Answer 18

Induce b cell proliferation and differentiation, IgE production, Promotes Th2/inhibit Th1, mast cell and basophil activation, mucus production by goblet cells

Question 19

Which cells produce IL-5

Answer 19

Th2 cells

Question 20

What is the activity of IL-5

Answer 20

Eosinophil differentiation and activation

Question 21

Which cells produce IL-13

Answer 21

Th2 cells

Question 22

What is the activity of IL-13

Answer 22

Bcell growth and differentiation, inhibits Th1 cells and macorphage inflammatory cytokines, ASSOCIATED WITH ASTHMA/ALLERGY

Question 23

Which cells produce IL-17

Answer 23

Th17 cells

Question 24

What is the activity of IL-17

Answer 24

Neutrophil recruitment, stimulates cytokine/chemokine production by fibroblasts and epithelial cells, dendritic cells induce Th17 cells from CD4 cells with high levels of TGF-beta, IL-23, and IL-6 during activation

Question 25

Which cells produce TGF-beta

Answer 25

Th cells, Tregs

Question 26

What is the activity of TGF-beta

Answer 26

inhibits much of innate immunity, anti-inflammatory, recruits macrophages promoting cleanup, promotes sIgA

Question 27

Which cells produce IFN-alpha/beta

Answer 27

Induced by virally infected cells GOOD NEIGHBOR CYTOKINE

Question 28

What is the activity of IFN-alpha/beta

Answer 28

Antiviral, increased MHC class I expression, NK cell activation, macrophage activation

Question 29

Which cell type is stimulated by SCF, IL-3, IL-1 during hematopoesis

Answer 29

Pluripotent stem cell

Question 30

Which cell type is stimulated by IL-7 during hematopoesis

Answer 30

Precursor T and B cells

Question 31

Which cell type is stimulated by GM-CSF during hematopoesis

Answer 31

Myeloid stem cell (gives rise to erythrocyte, neutrophil, macrophage, eosinophil, basophil, platelets)

Question 32

Which cell type is stimulated by IL-4 during hematopoesis

Answer 32

Basophil

Question 33

Which cell type is stimulated by IL-5 during hematopoesis

Answer 33

Eosinophils

Question 34

Which cell type is stimulated by M-CSF during hematopoesis

Answer 34

Monocyte -> Macrophage

Question 35

Which cell type is stimulated by G-CSF during hematopoesis

Answer 35

Neutrophil

Question 36

Which cell type is stimulated by EPO during hematopoesis

Answer 36

Erythrocyte