Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

Which cells produce IL-1

A

Macrophage, endothelium, epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the purpose of IL-1

A

Fever, synthesis of acute phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which cells produce IL-6

A

Macrophages, endothelium, epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the activity of IL-6

A

Fever, acute phase proteins, and b-cell proliferation of Ab producing cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which cells produce TNF-alpha

A

Macrophages, Tcells (Th1 cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the activity of TNF-alpha

A

fever, synthesis of acute phase proteins, killing of tumor cells, muscle/fat catabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which cells produce IL-8

A

Macrophages, fibroblasts, endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the activity of IL-8

A

neutrophil chemoattractant and activation, endothelial cell activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which cells produce IL-12

A

Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the activity of IL-12

A

Promote Th1 pathway, NK cell activation and IFN-gamma synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which cells produce IL-10

A

Macrophages, Th2 cells, Tregs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the activity of IL-10

A

Promotes Th2 pathway, inhibits Th1, inhibits macrophage proinflammatory cytokine release, increases apoptotic death of neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which cells produce IL-2

A

Th cells (naive and Th1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the activity of IL-2

A

Tcell growth factor, enhanced NK cell activity, induction of bcell Ig production (+/-)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which cells produce IFN gamma

A

Th1 cells, CD8 cells, NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the activity of IFN gamma

A

Macrophage activation, antiviral, NK cell activation, increased expression of class I and class II MHC, inhibits Th2 pathway, increases Th1 pathway, promotes class switching B cells to IgG2 while inhibiting IgE

17
Q

Which cells produce IL-4

A

Th2 cells

18
Q

What is the activity of IL-4

A

Induce b cell proliferation and differentiation, IgE production, Promotes Th2/inhibit Th1, mast cell and basophil activation, mucus production by goblet cells

19
Q

Which cells produce IL-5

A

Th2 cells

20
Q

What is the activity of IL-5

A

Eosinophil differentiation and activation

21
Q

Which cells produce IL-13

A

Th2 cells

22
Q

What is the activity of IL-13

A

Bcell growth and differentiation, inhibits Th1 cells and macorphage inflammatory cytokines, ASSOCIATED WITH ASTHMA/ALLERGY

23
Q

Which cells produce IL-17

A

Th17 cells

24
Q

What is the activity of IL-17

A

Neutrophil recruitment, stimulates cytokine/chemokine production by fibroblasts and epithelial cells, dendritic cells induce Th17 cells from CD4 cells with high levels of TGF-beta, IL-23, and IL-6 during activation

25
Q

Which cells produce TGF-beta

A

Th cells, Tregs

26
Q

What is the activity of TGF-beta

A

inhibits much of innate immunity, anti-inflammatory, recruits macrophages promoting cleanup, promotes sIgA

27
Q

Which cells produce IFN-alpha/beta

A

Induced by virally infected cells GOOD NEIGHBOR CYTOKINE

28
Q

What is the activity of IFN-alpha/beta

A

Antiviral, increased MHC class I expression, NK cell activation, macrophage activation

29
Q

Which cell type is stimulated by SCF, IL-3, IL-1 during hematopoesis

A

Pluripotent stem cell

30
Q

Which cell type is stimulated by IL-7 during hematopoesis

A

Precursor T and B cells

31
Q

Which cell type is stimulated by GM-CSF during hematopoesis

A

Myeloid stem cell (gives rise to erythrocyte, neutrophil, macrophage, eosinophil, basophil, platelets)

32
Q

Which cell type is stimulated by IL-4 during hematopoesis

A

Basophil

33
Q

Which cell type is stimulated by IL-5 during hematopoesis

A

Eosinophils

34
Q

Which cell type is stimulated by M-CSF during hematopoesis

A

Monocyte -> Macrophage

35
Q

Which cell type is stimulated by G-CSF during hematopoesis

A

Neutrophil

36
Q

Which cell type is stimulated by EPO during hematopoesis

A

Erythrocyte

Immunology (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions