Cytokines Flashcards
1
Q
IL-1
A
- Secreted by macrophages
- pyrogen - fever, acute inflammation
- activates endothelium to express adhesion molecules
- indues chemokine secretion to recruit leukocytes
2
Q
Il-6
A
- secreted by macrophages
- pyrogen
- also secreted by Th2
3
Q
IL-8
A
- secreted by macrophages
- major chemotactic factor for neutrophils
4
Q
Il-12
A
-secreted by macrophages
-induces differentiation of T cells in Th1
activates NK cells
-also secreted by B cells
5
Q
TNF-a
A
mediates septic shock
- secreted by macrophages
- activates endothelium
- causes leukocyte
6
Q
IL-2
A
- secreted by all T cells
- stimulates growth of helper, cytotoxic and reg T cells
7
Q
IL-3
A
- secreted by all T cells
- supports the growth and differentiation of bone marrow cells
8
Q
IFN-gamma
A
- secreted by TH1
- makes macrophages more microbicidal
- suppressed TH2
- has antiviral and antitumor properties
- increases MHC 1 and II expression and antigen presentation in all cells.
9
Q
IL-4
A
Induces differentiation into TH2 cells
- promotes growth of B cells
- enhances galls switching to IgG and IgE
10
Q
IL-5
A
- secreted by TH2
- promotes differentiation of B cells
- enhances class switching to IgA
- stimulates the growth and differention of eosinophils
11
Q
IL-10
A
- secreted by TH2
- modulates inflammatory response
- inhibits actions of activated t cells and TH1
- also secreted by regulatory t cells
