Complement Flashcards
1
Q
Classic pathway
A
IgG or IgM mediated
2
Q
Alternative pathway
A
microbe surface molecules
3
Q
lectin pathway
A
mannose or other sugars on microbe surface
4
Q
C1
A
C1 converts C2 to C2A and C2B
-C1 converts C4 to C4b
5
Q
C4bC2a
A
-converts C3 to C3b
6
Q
C3B
A
- opsonization
- C4b C2a C3b (C4b2a3b) converts C5 to C5b
7
Q
C5b
A
c5b along with C6-c9 form MAC –> lysis, cytoxicity
8
Q
C3a and C5a
A
anaphylaxis
-c5a neutrophil chemotaxis
9
Q
alternative pathway C3
A
-turns in to C3b with D turning B to Bb making C3bBb which can convert more C3 to C3b and C3a which then goies on to convert C5
