Cytokine signalling Flashcards
1
Q
What are cytokines?
A
Small, secreted signalling molecules
2
Q
What are cytokine signals often involved in?
A
Immune responses
3
Q
What type of differentiation is controlled by cytokines?
A
Blood cell differentiation
4
Q
What is Epo?
A
Erythropoietin - induces the differentiation of red blood cells
5
Q
What is the structure of cytokine receptors?
A
Highly conserved, 2 extracellular ligand binding domains. The receptor is already dimerized and isn’t catalytic, and is associated with Y kinases instead
6
Q
What is JAK kinase?
A
Y kinases tightly bound to cytokine receptors that will phosphorylate each other and the receptor, and recruit STAT transcription factors
