Cytokine Review Flashcards
Binds to macrophage membrane, enabling macrophages to activate lymphocytes that come in contact with them:
IL-1
Stimulates the development and clonal expansion of T helper 2 subset from naïve CD4 T cells:
IL-4
Main source is T helper 1 cells. Autocrine stimulation of proliferation and differentiation of T helper cells:
IL-2
Main activity is immunoregulatory that suppresses the Cell Mediated Immunity (CMI) response.
IL-10
Principal cytokine that stimulates growth and differentiation of eosinophils:
IL-5
Stimulates the synthesis of acute phase proteins:
IL-6
Stimulates endothelial expression of tissue factor, a potent activator of coagulation:
TNF
Stimulates the induction of T helper 1 subset from naïve CD4 T cells:
IL-12
These cytokines inhibit virus replication and increase expression of MHC class I:
Interferons
Name two interleukins that stimulate the growth and differentiation of bone marrow precursor cells:
IL-3 and IL-7
Involved in migration and activation of cells, especially phagocytic cells and lymphocyte
chemokines
Most dangerous of all cytokines:
TNF-alpha
Most important cytokine for growth and differentiation of T and B lymphocytes:
IL-7
IgE isotype switching:
IL-4
Principal activator of macrophages:
IFN-gamma
