Cytogenetics Flashcards
t(14;18)
Follicular lymphoma (IgH:Bcl2)
t(11;14)
Mantle cell lymphoma (cyclin D:IgH)
t(8;14)
Burkitt Lymphoma (c-myc:IgH)
t(2;8)
Burkitt Lymphoma
t(8;22)
Burkitt Lymphoma
t(11;18)
Marginal zone lymphoma
t(9;22)
**Philadelphia chromosome, BCR-ABL fusion increases TK activity (CML or poor prognosis B-ALL)
t(15;17)
AML (specifically APL; retinoic acid receptor disruption) *good prognosis
t(8;21)
AML *good prognosis
inversion 16/t(16;16)
AML *good prognosis
inversion 3/t(3;3)
AML *poor prognosis
Monosomy 5
MDS or AML with myelodysplasia-related changes *poor prognosis
Monosomy 7
MDS or AML with myelodysplasia-related changes *poor prognosis
t(2;5)
Anaplastic large cell lymphoma
t(12;21)
B-ALL *good prognosis