Cytogenetics Flashcards

1
Q

t(14;18)

A

Follicular lymphoma (IgH:Bcl2)

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2
Q

t(11;14)

A

Mantle cell lymphoma (cyclin D:IgH)

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3
Q

t(8;14)

A

Burkitt Lymphoma (c-myc:IgH)

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4
Q

t(2;8)

A

Burkitt Lymphoma

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5
Q

t(8;22)

A

Burkitt Lymphoma

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6
Q

t(11;18)

A

Marginal zone lymphoma

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7
Q

t(9;22)

A

**Philadelphia chromosome, BCR-ABL fusion increases TK activity (CML or poor prognosis B-ALL)

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8
Q

t(15;17)

A

AML (specifically APL; retinoic acid receptor disruption) *good prognosis

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9
Q

t(8;21)

A

AML *good prognosis

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10
Q

inversion 16/t(16;16)

A

AML *good prognosis

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11
Q

inversion 3/t(3;3)

A

AML *poor prognosis

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12
Q

Monosomy 5

A

MDS or AML with myelodysplasia-related changes *poor prognosis

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13
Q

Monosomy 7

A

MDS or AML with myelodysplasia-related changes *poor prognosis

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14
Q

t(2;5)

A

Anaplastic large cell lymphoma

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15
Q

t(12;21)

A

B-ALL *good prognosis

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16
Q

q(12;21)

A

AML with cytogenetic abnormalities