8- Lymph node VM Flashcards

1
Q

Where are lymphocytes generated and become mature?

A

In the primary lymphatic organs (BM and thymus)

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2
Q

Where do lymphocytes mount an immune response?

A

Secondary lymphatic organce (lymph nodes)

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3
Q

What is the “mesh” support system of secondary lymphatic organisms? What is it composed of?

A

Stroma (made of reticular fibers)

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4
Q

What are the main cells of the lymph node parenchyma and where are they located?

A
  • B cells (peripherally in follicles within the cortex)
  • T cells and macrophages (in the paracortex and medulla)
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5
Q

Contrast the appearance of primary and secondary lymphoid follicles; why are they different?

A
  • primary= uniform dark staining (consist mostly of naive B cells)
  • secondary= lighly staining germinal ceneter surrounded by darker staining mantle zone (indicates B cells have been activated by the presence of a foreign antigen in the lymph fluid)
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6
Q

What is the functional significance of a germinal center in a lymph follicle?

A

A germinal center indicates that new B cells are being produced in response to an antigenic stimulus

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7
Q

What is the functional significance of high endothelial venules in the lymph node?

A

HEVs are the “conduit” by which lymphocytes enter and are sequestered within lymph nodes

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8
Q

When you palpate a patient’s cervical “swollen glands”, what are you really palpating? What is happening at the cellular level in these structures?

A
  • Palpating lymph nodes that are enlarged and have triggered a pain response
  • Nodes are enlarged due to reactive changes in the lymph node including:
    • follicular hyperplasia (B cell proliferation forming germinal centers)
    • paracortical hyperplasia (T cell proliferation)
    • sinus histiocytosis (expanded sinuses)
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