Cytochrome P450

Question 1

Many of the major pharmacokinetics interaction between drugs are due to hepatic ________

Answer 1

Cytochrome P450

Question 2

Isoenzymes are a group of heme-containing enzyme embedded primarily and the lipid bilayer of the endoplasmic reticulum of hepatocytes it takes a part of metabolism of many drugs, steroids and carcinogens

Answer 2

Cytochrome P450

Question 3

Drug interaction involving the p450 isoforms generally are the two types

Answer 3

Enzyme induction or enzyme inhibition

Question 4

______Reduce metabolism were as ________ can increase it.

Answer 4

Enzyme inhibition
Enzyme induction

Question 5

As have been shown in a recent death caused by dysrhythmia or bone marrow (haematopoetic) inhibition due to combine administration of

Answer 5

Terfenadine and ketoconazole, erythromycin and intraconazole, and sorivudine and flouropyrimidines

Question 6

What are the six main enzyme attributed by p450 enzyme

Answer 6

CYP 1A2, 2C9, 2C19, 2D6, 2E1 AND 3A4

Question 7

This enzymes are most significant cyp enzyme in terms of quantity

Answer 7

CYP3A4 and CYP2D6

Question 8

This enzyme is found not only in the liver but also in the gut wall, where it may serve as a primary defense mechanism

Answer 8

CYP3A4

Question 9

CYP1A consist of two enzymes

Answer 9

1A1 AND 1A2

Question 10

Is not significantly expressed in the liver. It is found mainly in the lungs, mammary glands, placenta and lymphocytes.

Answer 10

CYP1A1

Question 11

it is an enzyme involved in the inactivation of procarcinogens and is highly induced by polycystic aromatic hydrocarbon ( PAHs) which are found in cigarette smoke.

Answer 11

CYP1A1

Question 12

Is expressed mainly in the liver and is induced by cigarette smoking. It is also induced by the indigestion of some food stuff such as cruciferous vegetables as well as barbecued or charboiled food

Answer 12

CYP1A2

Question 13

Some drugs such as ____ may induce CYP 1A2 activity

Answer 13

Omeprazole

Question 14

Drugs which are known to be metabolized by CYP1A2 include:

Answer 14

Theophylline, caffiene, imipramine, and phenacitin

Question 15

Previously known as couramin hydroxylase

Answer 15

CYP2 FAMILY

Question 16

What substance thus broken down the CYP2 family

Answer 16

Nicotine

Question 17

What are the two CYP2C subfamily

Answer 17

CYP2C9 AND CYP2C19

Question 18

Is the anticoagulant warfarin

Answer 18

CYP2C9

Question 19

Other drugs metabolized by CYP2C9 include:

Answer 19

Non-steroidal anti-inflammatory drugs ( NSAIDS ) ( Including COX-2 selective inhibitors), the hypoglycemic agents tolbutamide, phenytoin and the angiotensin- II receptor antagonist losartan

Question 20

has a number of commonly used substrates including the benzodiazepine diazepam, the protein pump inhibitor omeprazole, propanolol and the antidepressive amitriptyline

Answer 20

CYP2C19

Question 21

It has been demonstrated that poor metabolizers who are prescribed proton pump inhibitor omeprazole as a part of therapy against helicopactor pylori infection may have significantly better clinical outcomes ad compared to the group of patient homozygous for the normal

Answer 21

Cyp2c19

Question 22

A large number of drugs are metabolized by this enzyme including a number of anti-arrhythmics such as flecanide and encainide, tricyclic antidepressant ,some beta blockers and a number of selective serotonin re-uptake inhibitors

Answer 22

CYP2D6