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Pharma Block 1 > CYP > Flashcards

CYP Flashcards

1
Q

CYP1A1

A

AhR inducible
polycyclic hydrocarbons–>associated with cancer
extrahepatic (lung)

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2
Q

CYP1A2

A

polycyclic hydrocarbons–>associated with cancer
liver only
caffeine

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3
Q

CYP1B1

A

important for fetal development

Congenital glaucoma

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4
Q

CYP2A6

A

nicotine

polymorphic

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5
Q

CYP2B6

A

CAR inducible
ecstacy
polymorphic

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6
Q

CYP2C

A

30% of all commonly used drugs

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7
Q

CYP2C19

A

Plavix

polymorphic

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8
Q

CYP2D6

A

produgs: hydrocodon and tamoxifen
1st identified polymorphic CYP; cancer risk in rapid metabolizers
dextromethorphan test; SSRI inhibits

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9
Q

CYP2E1

A

ethanol, acetamenophen

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10
Q

CYP3A4/5

A

~50% of drugs
inducible; polymorphic
inhibited by grapefruit juice/cemetidine; induced by phenobartbital and rifampin
PXR inducible

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Pharma Block 1 (5 decks)

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