Antianginal Flashcards
Propanolol
Beta blocker
Tx for angina pectoris and following an MI (NOT variant angina)
Side effects: fatigue, bradycardia, bronchospasm
Nitrovasodilators
Nitroglycerin, Isosorbide dinitrate, amyl nitrate, sildenafil
Relax smooth mm by releasing NO, arteriolar and venous dilatation, relieves coronary vasospasm
Tx for angina pectoris and variant angina
Nitroglycerin
Nitrovasodilator
Develop tolerance rapidly
Dose: Venous
Calcium Channel Blockers
Nifedipine (Dihydropyridine)»Verapamil>Diltiazem
Block L-type voltage gated Ca channels
Tx for angina pectoris, variant angina
Nifedipine
Dihydropyridine Ca channel blocker
Pure arterial vasodilator, no effect on heart
Diltiazem, Verapamil
Ca channel blockers
Arterial vasodilator, Reduce cardiac contractile force and heart rate
Do NOT give with Beta blocker
Which classes of drugs can be given with beta blockers?
nitrovasodilators and dihydropyridines (nifedipine)