Cyndi - Week 9 - Exam 4 Flashcards
what are the different cultural and ethnic disparities for women’s health?
- Access differences
- Insurance
- Money
- Quality of care
- Health knowledge/advocacy
- *Caucasian highest incidence - Hispanic/African American women increased death d/t Poverty level**
what are the different types of breast cancer? (4)
• Non‐invasive carcinoma
- DCIS‐ductal carcinoma in situ, LCIS‐lobular carcinoma in situ
• Invasive carcinoma
◦ Ductal – 80% -vascular - at risk for metastasis
◦ Lobular – 20%
• Inflammatory breast cancer
• Paget’s disease of the nipple - Hardening and thickening and sore; skin is dimpled/orange peeled
Misdiagnosed as mastitis
what are the risk factors for breast cancer?
• Age (50% - 65 years or older) • Ethnicity • Hormone status • Heredity • Familial - ↑ risk if first degree • DNA testing BRCA 1, 2 mutations - BRCA repair tissue in breast - too much production - mutation • Hormone status • Access • Other - Table 52‐2 *** Men’s risk factors • High estrogen levels - male with BRCA mutation • Obesity d/t higher level of estrogen • Teach breast self‐exam for early diagnosis!
what are the most common sxs for breast cancer?
• New lump or mass • Nontender lump • 50% in upper outer quadrant of breast - close to lymph so can go into blood stream • Nipple changes OR • Tender, soft, or rounded lump
what are the uncommon sxs for breast cancer?
- Swelling of all or part of breast OR arm (lymphedema)
- Skin irritation or dimpling
- Breast or nipple pain
- Nipple retraction (turning inward)
- Redness, scalyness, thickening of nipple or skin
- Nipple discharge (other than breast milk)
what are the diagnostic tests used for breast cancer?
• radiologic • biopsy • axillary lymph node status • initial detection vs monitoring • Tumor size • HER2 marker • Hormone receptor status - Estrogen - Progesterone • Cell proliferative indices • Cancer markers - Diagnosis and monitoring • DNA testing • Genomic assay
what are the radiologic tests done for BC?
- mammography (at 40; BRCA/hx at 25)
- MRI
- US
- PET scan (gold standard)
what does a BC tissue biopsy consist of?
- grading and staging
- tissue specimen tests for type of cancer
what does axillary lymph node status consist of?
- lymphatic mapping
- sentinel node dissection (the main node - most concentration of cancer)
- *tissue that has estrogen/progest. receptors have greater risk
what is triple negative breast cancer?
don’t have HER2 marker, estrogen or progesterone; so it’s harder to tx
what is differentiation in breast cancer?
the extent to which cancerous cells resemble normal cells
how are tumors graded?
graded for how closely they resemble parent tissue
- grades 1 (better) to 3 (worse)
what is TNM staging based on?
- 0 - 4 stages
- based on tumor size, node involvement, and metastasis
what are the complications of differentiation?
- recurrence in local, regional, or distant sites
what are the different tx for BC?
- meds
- surgery
- radiation
- pt education
- mastectomy post op care
what are the meds used for BC?
- chemo (may have after surgery to clean up)
- hormone therapy - Tamoxifen
- biologic and targeted therapy - Herceptin
- bisphosphonates - new adjuvant tx?
TEST: how does tamoxifen work?
its a estrogen receptor blocker
- estrogen helps produce breast tissue
- slows the process down
what surgeries are used as tx for BC?
**primary tx** ◦ Lumpectomy ◦ Mastectomy -Radical vs modified radical ◦ Prophylactic ◦ Lymph node dissection
TEST: what is the difference between a radical mast and a modified radical mast?
radial mast: whole breast, lymph and pectoral
modified: whole breast and lymph (NO pec)
what is the pt education for BC tx?
- tx plan (monitoring and follow up)
- psychosocial issues
- body/sexual image
- health promotion