Cvs 3 - Part 2 Flashcards
The 3 chatacholemines are?
Epinephrine, norepinephrine and dopamine
What is the source of norepinephrine in the human body?
Adrenal Medulla, Post ganglionic fibers of the sympathetic nerves
What is the source of epinephrine in the human body?
Adrenal medulla
Epinephrine is the more potent Vasoconstrictor so it is used for?
as the “Last Whip” in any attempt to revive the failing cardiovascular system
The kidney primarily regulates what?
And How?
The blood pressure of the body by production of renin
When is renin released?
• Renin is released by the Kidney when low renal perfusion (low blood pressure), low sodium levels & low blood volume are present
Angiotensinogen is produced by the
Liver
Angiotensin function on blood vessels
causes the blood vessels to constrict (does not have a potent effect)
Angiotensin 1 is produced when?
when Renin acts upon Angiotensinogen
Angiotensin converting enzyme (A.C.E.) function
converts Angiotensin 1 into Angiotensin 2 (which is more potent)
• If medications block this enzyme or this enzyme’s receptors are given to a diabetic, hypertensive, or heart patient, their life-span may be prolonged for up to 10-30 years
A.C.E
Why does blocking A.C.E prolong the life of certain patients
delays the onset of End Stage Renal disease and other end stage organ condition
What are ACE inhibitors
Prevents the formation of angiotensin 2 by blocking angiotensin converting enzyme
What are ACE receptor inhibitors?
Prevents the development of angiotensin 2
What are the 4 actions of angiotensin 2?
Direct presser
Stimulates the zona glomerosa of the adrenal cortex
Stimulate the Adrenal Medulla and Sympathetic Nervous System’s headquarters.
Stimulates the pituitary gland and the hypothalamus
What happens when angiotensin 2 stimulates the zona glomerosa of the adrenal cortex
making it produce and secrete aldosterone
What happens when angiotensin 2 acts as a direct presser
increases peripheral resistance, Increases blood pressure
When Stimulated the Adrenal Medulla and Sympathetic Nervous System’s headquarters.
Increase Norepinephrine and epinephrine availability
What happens when angiotensin 2 Stimulates the pituitary gland and the hypothalamus
Tells them to realese more ADH (vasopressin)
Vasopressin function on smooth muscle
Vasopressin is a direct presser to stimulates the smooth muscles to contract. Peripheral resistance is increased leading to elevated Blood pressure
Since Blood Pressure = Cardiac Output (C.O)× Peripheral Resistance
ADH function
ADH also acts on the kidneys, which leads to increased reabsorption of water. This prevents the loss of water
ADH or vasopressin is produced by?
And secreted by?
Hypothalamus
Posterior Pituitary gland
What is the effect of aldosterone on kidney
acts on the kidney leading to increased reabsorption of sodium
What are the effects of epinephrine and norepinephrine on the body
increased PR and Heart rate, and increased blood pressure