CV Pharmocology Flashcards

1
Q

What drugs are used in the treatment of CV diseases?

A

ACE Inhibitors
Beta Blockers
Calcium Antagonist
Diuretic

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2
Q

Describe the sequence of drugs used to treat normal hypertension

A
  1. Patients younger that 55 start with an ACEI/ARB and older patients with Calcium Antagonist
  2. Then C/A
  3. Then a diuretic
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3
Q

What drugs are used to treat severe hypertension?

A

Beta or alpha blocker or spironolactone

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4
Q

What drugs are used in all patients with CHF?

A

DAB
Diuretic to rid the body of fluid retention
ACE Inhibitor and Beta blocker to remodel the heart

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5
Q

If CHF patients are still exhibiting signs like breathlessness after initial drug treatment, what drugs should be used?

A

Spironolactone and Eplerenone

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6
Q

Who would receive Cardiac synchronisation therapy?

A

CHF patients with long QRS segments on an ECG where drug treatment has failed

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7
Q

What can be done for patients with severe CHF

A

implantable cardiac defibrillators

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8
Q

What is sacubitril vasartan?

A

new dual drug used in severe heart failure that replaces ACEI or ARB

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9
Q

What is used to prolong survival in patients with Angina?

A

SAAB

Statin, aspirin, ACE inhibitor and beta blocker

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10
Q

What is used to relieve the symptoms of angina

A

beta blocker
calcium antagonist/nitrates
coronary angioplasty
New antianginals - ivabradine and ranolazine

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11
Q

How can chest pain be classified?

A

Non cardiac or cardiac
cardiac chest pain can be classified as troponin -ve which is called troponin -ve ACS.
troponin +ve can be classified as a STEMI or non-STEMI

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12
Q

Who might receive fondaparinux?

A

STEMI patient

synthetic pentasaccharide that inhibits activated factor X

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13
Q

describe the emergency management of STEMI

A

aspirin with angioplasty or thrombolysis

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14
Q

decribe the similarities in treatment of STEMIs and non-STEMIs

A

they both receive aspirin and clopidogrel/ticagrelor

they both receive SAABs as prophylaxis

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15
Q

describe the differences in treatment of STEMIs and non-STEMIs

A

use of angioplasty is selective in non-STEMIs

STEMIs recieve heparin/fondaparinux

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16
Q

how is troponin -ve ACS syndrome treated

A

SAAB with selective anioplasty

17
Q

if someone with ACS has ongoing chest pain, what may they recieve

A

a glycoprotein Iib/IIIa inhibitor like tirofiban

18
Q

what are the targets of treatment of atrial fibrillation?

A

prevention of emboli using warfarin/rivaroxiban
control of rate using beta blocker, digoxin
control of rhythm (seldom) using DC cardioversion, amiodarone in CHF, and sotalol/slecinide if heart structure is normal

19
Q

what causes stroke

A

cerebral thrombosus, embolus and haemorrhage

20
Q

what is the role of a CT scan in the treatment of stroke?

A

differentiates between clot or haemorrhage

21
Q

how is a non haemorrhagic stroke treated?

A

emergency thrombolysis, aspirin and clopidogrel

statin, ACE inhibtior and indapamide

22
Q

what is the targets of antianginal drugs

A

decrease the metabolic demands on the muscle by decreasing the preload/afterload or slowing down the heart

23
Q

What beta blockers are used in angina

A

bisoprolol and atenolol

24
Q

what is carvedilol used for

A

patients with CHF

25
Q

which beta receptors are important in angina

A

beta 1 - control rate of the heart and thus correlates to oxygen consumption

26
Q

what is the mechanism of calcium antagonists

A

vasodilator
prevents constriction of smooth muscle
prevent opening of voltage gated L type Ca2+ channels upon depolarisation
preventing entry of extracellular calcium

27
Q

Name types of calcium antagonists and give examples

A

DHP derivatives eg. amlosipine and lercandipine

Rate limiting eg. verapamil and dilitiazen

28
Q

what effect of calcium antagonists is important for variant angina

A

dilation of coronary vessels

29
Q

what calcium antagonists are safe for CHF patients

A

amlodipine and lecanidipine

30
Q

what are the contraindications of verapramil and dilitiazem?

A

heart failure, brachycardia, AV block, beta blocker