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CRRAB I--Wk 1 > CV Infectious Disease--Diebel > Flashcards

CV Infectious Disease--Diebel Flashcards

1
Q

3 layer of the heart: 3 inflammatory diseases of layers of the heart

+ causative organisms

A

endocarditis: Staph and Strep

myocarditis: Coxsackie B, adenovirus

pericarditis: Coxsackie A and B, echovirus, influenza

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2
Q

When are coxsackie virus infections most common?

A

summer

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3
Q

When is one most likely to have pericarditis (time of year)?

A

summer

coxsackie most prevelent in summer months

(all enteroviruses)

fecal-oral transmission

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4
Q

IV drug users are most likely to have this causative organism causing endocarditis

A

S. aureus

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5
Q

Two major categories of infectious endocarditis

A

acute

subacute

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6
Q

Acute infectious endocarditis Sx

A

hectically febrile

rapidly damages cardiac structures

seeds distally via sepsis

death in weeks w/o Tx

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7
Q

Subacute infectious endocarditis Sx

A

low infectious course

slow damage

rarely seeds via sepsis

gradually progressive

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8
Q

IV drugs can cause infectious endocarditis in this location that is unusual

A

tricuspid valve

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9
Q

Two most common points of infection for infectious endocarditis

A

mitral and aortic valves

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10
Q

protein A

S. aureus

A

binds Fc region of IgG

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11
Q

coagulase

S. aureus

A

forms fibrin clot around organism

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12
Q

hemolysins and leukocidins

S. aureus

A

destroy RBC and WBC

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13
Q

hyaluronidase

S. aureus

A

breaks down CT, deep tissue invasion

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14
Q

staphylokinase

A

lyses formed clots

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15
Q

lipase

S. aureus

A

breaks down fat

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16
Q

S. aureus virulence factors

A

biofilm formation

capsule

adhesins

pathogenicity islands

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17
Q

Strepococcal viridans species are a common cause of infectious endocarditis, especially in what situation?

A

post-dental procedures

common oral flora

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18
Q

Common Strep viridans species

A

S. mutans

19
Q

S. mutans classification

A

bacteria

Gram +

Cocci

Catalase -

alpha-hemolytic

bacitracin-resistant

S. mutans

20
Q

Enterococcus species

cause endocarditis in which populations

A

young women after OB procedures

older men after genitourinary procedures

21
Q

Enterococcus species virulence factors

A

pili

surface proteins

extracellular enzymes

hyaluronidases

22
Q

Complications of what infection leads to rheumatic fever?

A

S. pyogenes pharyngitis

23
Q

S. pyogenes

classification

A

Bacteria

Gram +

Cocci

Coagulase -

Beta-hemolytic

bacitracin-sensitive

S. pyogenes

24
Q

Major unforgettable S. pyogenes virulence factor

A

M-protein

normally resists phagocytosis

antibodies to M-protein cross-react with mycardial meromyosin in some individuals and causes rheumatic heart disease

25
Q

M-protein in S. pyogenes normally…

A

resists phaogcytosis

26
Q

Sx of rheumatic fever

A

2-4 week post-strep

pain/swelling of large joints

fever

weakness

muscle aches

SOB

chest pain

N/V

hacking cough

circular rash

lumps under skin

27
Q

Rheumatic fever can cause what kind of damage to the mitral valve

A

stenosis

inability to open all the way

28
Q

Antibodies and rheumatic fever

A

formed against M-protein in S. pyogenes but cross-react with meromyosin in heart

29
Q

Age group of rheumatic fever

A

5-15 y/o

30
Q

Myocarditis organisms

A

coxsackie B

adenovirus

31
Q

Pericarditis organsisms

A

coxsackie A and B

echovirus

influenza

32
Q

coxsackie classification

A

virus

ssRNA(+), Group IV

nonsegmented

icosohedral nucleocapsid

non-enveloped

picornavirus

enterovirus

coxsackie A and B

33
Q

Rocky mountain spotted fever organism

A

R. rickettsii

34
Q

Rocky mountain spotted fever Tx

A

doxycycline

35
Q

Specialness of rocky mountain spotted fever, pathogenicity

A

obligate intracellular organism

requires host ATP

36
Q

Rash in rocky mountain spotted fever

A

on palms and soles, spreading centrally

37
Q

FnbpA (elastin, collagen, fibronectin) binding proteins

  • function
  • organism
A

adhesion/biofilm formation

S. aureus

38
Q

Coagulase

-organism

A

S. aureus

39
Q

Leukocidin

-organism

A

S. aureus

40
Q

Capsule

-organism

A

S. aureus

41
Q

SdrG (SD-repeat containing protein G)

  • function
  • organism
A
  • adhesion
  • S. epidermidis
42
Q

CAR binding proteins

  • function
  • organism
A

coxsackie-adenovirus cellular receptor

  • adhesion
  • coxsackie A and B, adenovirus
43
Q

OmpA and OmpB

  • function
  • organism
A
  • adhesion
  • R. rickettsia
44
Q

Type 4 secretion system (T4SS)

  • function
  • organism
A
  • host cell entry
  • R. rickettsia

CRRAB I--Wk 1 (12 decks)

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