Cutaneous Manifestations of systemic diseases Flashcards

1
Q

What are the cutaneous changes seen in associated with underlying liver dysfunction? What does it stem from?

A

-spider angiomas
-palmar erythema
from excess estrogen

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2
Q

What are the cutaneous changes seen in associated with underlying renal dysfunction? What does it stem from?

A

-pruritis
-Nail changes: lindsay’s nails or half and half
from uremia and atypical metabolism

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3
Q

What are the cutaneous changes seen in associated with underlying cardiovascular problems? What does it stem from?

A

stasis dermatitis -lower extremity edema
also: erythema, hyperpigmentation, xerosis, pruritis, ulcerations
due to venous insufficiency

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4
Q

What are the cutaneous changes seen in associated with underlying pulmonary dysfunction? What does it stem from?

A

clubbing of fingernails

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5
Q

What are the cutaneous changes seen in associated with underlying GI dysfunction? What does it stem from?

A

pyoderma gangrenosum-inflammatory on infectious ulcer, worsened by trauma
dx: must rule out other ulcers

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6
Q

What are the cutaneous changes seen in associated with underlying endocrine dysfunction? What does it stem from?

A

-Acanthosis Nigricans-velvety darkening of skin posterior neck mainly, also armpits
associated with diabetes
-hyperpigmentation palmar creases and gums in association with addison’s disease (e.g. JFK)

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7
Q

What skin findings are associated with IVD use and bacterial endocarditis infections?

A
  • Janeway lesions -painless septic emboli of bacterial endocarditis
  • Osler nodes -tender immune complex deposition, painful
  • splinter hemmorrhage on fingernails
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8
Q

What skin findings are associated with strep throat?

A

Erythema nodosum - non specific panniculitis- inflammation of fat, bruise like lesions on shin

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9
Q

What skin findings are associated with lupus?

A

Malar rash- butterfly rash
Raynaud’s -fingers turn colors in cold from white to blue to bright red
Discoid Lupus -hair

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10
Q

What skin findings are associated with dermatomyositis?

A
  • heliotrope rash around the eyes
  • shawl sign-a diffuse, flat, erythematous lesion over the back and shoulders or in a “V” over the posterior neck and back or neck and upper chest
  • gottron’s sign on knees and elbows
  • Gottrons papules on the hands
  • dilated capillary loops around nail beds
  • muscle with increased CK
  • should be screened for malignancy can be paraneoplastic phenomenon
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11
Q

What skin findings are associated with malignancy such as breast cancer?

A

E.g. metastatic adenocarcinoma of the breast - cutaneous metastases. most commonly of breast, colon, ovarian, lung for women. Lung, colon, melanoma, oral SCC for men.

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12
Q

What skin findings are associated with glucagonoma?

A

Necrolytic migratory erythema. Annular rash in skin folds.

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13
Q

What skin findings are associated with HIV?

A
  • severe seborrheic dermatitis
  • severe herpes simplex
  • molluscum contagiosum
  • verruca vulgaris HPV
  • Karposi’s sarcoma HHV 8
  • disseminated cryptococcus
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14
Q

What skin findings are associated with nutritional deficiency (scurvy)?

A

-perifollicular hemorrhage and hemorrhagic changes of patients gums

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