Cutaneous Manifestation of Systemic Disease Flashcards
Describe the condition associated with this lesion.
Discoid Lupus: inflammation and scarring of the face, ears, and scalp and at times on other body areas. The ears are also a common place to find lesions.
Describe this condition
Scleroderma (CREST syndrome): autoimmune condition resulting in calcinosis, raynaud’s phenomenon, esophageal dysfunction (leading to difficulty swallowing), sclerodactyly (skin thickening on the fingers), and telangiectasias
Condition with very hypermobile joints and elastic skin.
Ehlers Danlos Syndrome: hypermobility of joints is mostly characteristic of Type III which is a defective Tenascin X gene encoding collagen)
Condition involved with poor healing time and bruising.
Ehlers Danlos Syndrome: most common in the vascular Type IV ED syndrome. Defective Type III collagen formation
What do these lesions indicate is circulating in the serum?
Yellow papules are most likely xanthomas indicating increased levels of triglycerides circuating in the blood.
Condition with a lot of causes including: autoimmune, drug-induced, physical obstruction and genetic defects.
Livedo Reticularis
Name and describe the condition that causes these lesions.
Sarcoidosis: systemic granulomatous inflammation that most commonly occurs in the lungs. In this case the granulomas are forming on the skin and can be caused by autoimmune disease, infection, or genetic disease.
Describe these lesions and why they are not common anymore.
Arsenic Keratosis: caused by arsenic intoxication. Not as common anymore because arsenic is no longer a component of medications.
Describe this lesion and some common causes.
Acanthosis Nigricans: caused by obesity, Type 2 DM, other endocrine disorders. Can also occur around and in the mouth.
Describe the condition associated with this lesion.
Paget Disease of the breast: considered migration of ductal carcinoma in situ out onto the nipple and areola. Similar morphologies can occur in bone and in vulvar tissue (extramammary pagets)
Name and describe this lesion.
Necrobiosis Lipoidica: necrotizing skin disease in diabetics.
Describe this symptom of an endocrine condition.
Pretibial Myxedema commonly seen in patients with Graves Disease.
Describe the cause of these lesions.
Mycosis Fungoides (cutaneous T cell lymphoma)
Condition that causes these lesions.
Neurofibromatosis Type 1: chromosomal mutation affecting the RAS gene in the cell cycle pathway. Leads to uncontrolled cell division.
Condition with abnormal heme production.
Porphyria Cutanea Tarda
Genetic disease with hamartomatous polyp formation in the intestines.
Peutz–Jeghers syndrome: hyperpigmented macules appear around the mouth and can spread across the face.
Condition linked to inflammatory bowel disease, rheumatoid arthritis, multiple myeloma or other immune system pathology that leads to cutaneous lesions.
Pyoderma Gangrenosum
Condition in IC patients forming these hemangiomas.
Kaposi Sarcoma from HHV-8 infection. Usually in AIDS patients.
Condition from normal flora overgrowth in IC patients.
Oral Thrush (Candidiasis)
Condition with Umbilicated lesions.
Molluscum Contagiosum: usually in HIV patients
