cutaneous drug eruptions

Question 1

what can trigger linear IgA disease

Answer 1

vancomycin

Question 2

90% of drug reactions are?
mediated by?
type?
assoc drugs

Answer 2

exanthematous
T cell mediated
type 4
drugs - penicillins, cephalosporins, anti epileptics

Question 3

examples of types 1-4 immune mediated reactions

Answer 3

type I - urticaria
type II - pemphigus/pemphigoid
type III - purpura/rash
type IV - erythema/rash

Question 4

RF’s for drug eruptions

Answer 4

young adults
female 
beta lactam compounds 
NSAIDs
viral infections
CF 
high molecular weight/hatpan forming compounds

Question 5

drugs that induce bullous pemphigoid

Answer 5

ACEI, penicillin, furosemide

Question 6

drugs that can induce SJS (erythema multiforme)

Answer 6

sulphonamides

anticonvulsants

Question 7

drug eruptions should be reported via ..

Answer 7

the yellow card scheme

Question 8

skin testing
not recommended for ?

can potentially trigger?

Answer 8

serum sickness reactions
T cell mediated reactions

can potentially trigger SJS, TEN, DRESS

Question 9

what is toxic epidermal necrolysis

Answer 9

severe life threatening skin condition where the epidermis lifts off from the dermis all over the body&raquo_space; very susceptible to infection

Question 10

what is drug reaction with eosinophilia and systemic symptoms (DRESS)

Answer 10

syndrome caused by exposure to certain medications 
rash
fever
inflammation of internal organs 
^^ eosinophils & lymphocytes
thrombocytopenia (low platelets)

Question 11

gold standard for suspected allergic contact dermatitis

Answer 11

patch testing

Question 12

testing if photo allergic dermatitis suspected

Answer 12

test against 2 sets of allergens

• one exposed to UV
• one not