Cutaneous Drug Eruptions Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

when does a cutaneous drug eruption usually resolve?

A

when the drug is withdrawn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

which age group is most likely to suffer a cutaneous drug eruption?

A

young adults

females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what underlying conditions can predispose to cutaneous drug eruptions?

A

viral infections

cystic fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the most common type of drug eruption?

A

exanthematous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what type of reaction is an exanthematous drug eruption?

A

delayed hypersensitivity (IV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

describe the appearance of an exanthematous eruption

A

widespread symmetrical rash

mucous membranes spared

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are common associated symptoms of an exanthematous eruption?

A

itch

fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

when does an exanthematous eruption occur?

A

4-21 days after first taking the drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

name four drugs associated with exanthematous eruptions

A

penicillin
erythromycin
allopurinol
NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the two possible processes behind an urticarial drug reaction?

A

immediate IgE mediated reaction on rechallenge

direct release of mast cell components on first exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

name four drugs that can cause urticarial drug reactions

A

beta lactam antibiotics
aspirin
opiates
NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are two types of bullous drug eruptions?

A

acneiform

AGEP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does AGEP stand for?

A

acute generalised exanthematous pustulosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

name three drugs that can cause an acneiform bullous drug eruption

A

glucocorticoids
androgens
lithium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

name three drugs that can cause AGEP

A

antibiotics
CCB
anti malarials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what three drugs can cause drug induced bullous pemphigoid?

A

ACEi
penicillin
furosemide

17
Q

what drug can trigger linear IgA disease?

A

vancomycin

18
Q

describe the appearance of a fixed drug eruption

A

well demarcated plaques

red and painful

19
Q

what body sites are often affected by fixed drug eruptions?

A

hands
genitalia
lips
occasionally the oral mucosa

20
Q

when a fixed drug eruption resolves, what can be seen?

A

persistent pigmentation

may re-occur

21
Q

name four drugs associated with fixed drug eruptions

A

tetracycline
paracetamol
NSAIDs
carbamazepine