Cutaneous Drug Eruptions Flashcards
when does a cutaneous drug eruption usually resolve?
when the drug is withdrawn
which age group is most likely to suffer a cutaneous drug eruption?
young adults
females
what underlying conditions can predispose to cutaneous drug eruptions?
viral infections
cystic fibrosis
what is the most common type of drug eruption?
exanthematous
what type of reaction is an exanthematous drug eruption?
delayed hypersensitivity (IV)
describe the appearance of an exanthematous eruption
widespread symmetrical rash
mucous membranes spared
what are common associated symptoms of an exanthematous eruption?
itch
fever
when does an exanthematous eruption occur?
4-21 days after first taking the drug
name four drugs associated with exanthematous eruptions
penicillin
erythromycin
allopurinol
NSAIDs
what are the two possible processes behind an urticarial drug reaction?
immediate IgE mediated reaction on rechallenge
direct release of mast cell components on first exposure
name four drugs that can cause urticarial drug reactions
beta lactam antibiotics
aspirin
opiates
NSAIDs
what are two types of bullous drug eruptions?
acneiform
AGEP
what does AGEP stand for?
acute generalised exanthematous pustulosis
name three drugs that can cause an acneiform bullous drug eruption
glucocorticoids
androgens
lithium
name three drugs that can cause AGEP
antibiotics
CCB
anti malarials
what three drugs can cause drug induced bullous pemphigoid?
ACEi
penicillin
furosemide
what drug can trigger linear IgA disease?
vancomycin
describe the appearance of a fixed drug eruption
well demarcated plaques
red and painful
what body sites are often affected by fixed drug eruptions?
hands
genitalia
lips
occasionally the oral mucosa
when a fixed drug eruption resolves, what can be seen?
persistent pigmentation
may re-occur
name four drugs associated with fixed drug eruptions
tetracycline
paracetamol
NSAIDs
carbamazepine
