CTC Endocrine

Question 1

Cah

Answer 1

90% 21 hydroxylase deficiency
Can’t make aldosterone or cortisol
Large cerebriform adrenals >4mm thick 20mm long
Boys present at 1-2 weeks with salt wasting crisis
Girls present on birth with ambiguous genitals

Question 2

Associated with phaeo

Answer 2

Vhl ts men2a men2b sw carney triad nf1

Question 3

Urinary catecholamines in neuroblastoma and phaeo

Answer 3

Vma hva

5hiaa is serotonin breakdown in carcinoid

Question 4

Men

Answer 4

Men1 pituitary adenoma (PRL) parathyroid hyperplasia >adenoma or carcinoma pancreatic NET (gastrinoma)
Men2a parathyroid hyperplasia, medullary thyroid cancer, phaeo
Men2b mtc, phaeo, marcanoid habitus, mucosal neuroma

Question 5

Carcinoid v lymphoma v gist locations

Answer 5

Carcinoid 45% JI - 90% TI, 31 CR, 16 app, 7 stomach
Lumphoma stomach>SB>colon
Gist stomach 60%>sb> 30%> oesophagus

Question 6

Vhl

Answer 6

Haemangiomas elst 10% cpp
Pancreatic cysts75%, serous cystsdenomas, net,
Renal cysts, phaeo 10%, clear cell rcc70%
Epididymis cystadenoma 55%

Question 7

TS

Answer 7

Tubers, sen, sega, rhabdomyoma, aml, lam, facial angiofibromas, seizures, retarded, clear cell rcc same rate but younger

Question 8

Thyroid cancer

Answer 8

Papillary popular calcified good prog responds i131. See microcalcs in nodal mets
Follicular 2nd haematogenous spread, 2nd best, responds i131. Hurthe cell is uncommon variant
Medullary men2a/b makes calcitonin (amyloid) not responsive
Anaplastic fucks shit up not responsive

Microcalcs, irregular microlubulated or spiculated margins, solid hypervscular, hypoechoic, taller than wide all bad.
Tirads 0 incomplete, 1 nothing, 2 benign, 3 prob benign, 4 suspicious, 5 likely cancer 6 proven ccancer
1-2-3 none, 4a1 4b2 4c3-4 5-5 bad things