CSF Flashcards

1
Q

3rd major body fluid

A

CSF

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2
Q

provides physiological system to supply nutrients to the nervous system

A

CSF

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3
Q

Functions of CSF

A
  1. Supply nutrients to CNS
  2. Remove metabolic waste
  3. Produce mechanical barrier to cushion the brain and spinal cord against trauma
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4
Q

Lines the brain and spinal cord

A

Meninges

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5
Q

3 Layers of Meninges

A
  1. Dura mater
  2. Arachnoid mater
  3. Pia mater
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6
Q

outer layer and lines the skull and vertebral canal

A

Dura mater

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7
Q

spider-like and filamentous inner membrane

A

Arachnoid mater

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8
Q

innermost layer and lines the surface of brain and spinal cord

A

Pia mater

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9
Q

It is between arachnoid mater and pia mater
It is where CSF flows

A

Subarachnoid space

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10
Q

specific part of brain that produces CSF

A

Choroid Plexus

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11
Q

The choroid plexuses are ____ that form the CSF from plasma by mechanisms of ____ under ____ and active transport secretion

A

capillary networks
selective filtration
hydrostatic pressure

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12
Q

T/F
chemical composition of the CSF
resemble an ultrafiltrate of plasma

A

FALSE
It does not resemble

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13
Q

rate of CSF production

A

20 mL/hr

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14
Q

A tightly fitting junctures structure of endothelial cells in the choroid plexus

A

Blood-brain barrier

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15
Q

Protects the brain from chemicals and other substances circulating in the blood that can harm the brain tissue

A

Blood-brain barrier

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16
Q

Disruption of BBB allows WBC, protein and other chemicals to enter CSF

A

Blood brain barrier

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17
Q

specimen collected for CSF

A

lumbar puncture/tap and cisternal puncture

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18
Q

pressure of patient when CSF is collected

A

90 and 180 mmHg

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19
Q

Volume collected/removed for CSF if the pressure is normal

A

20 mL

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20
Q

On closing, the pressure should be between

A

10 and 30 mmHg

21
Q

A marked decrease in pressure following this procedure suggests

A

cerebellar herniation or spinal cord compression

22
Q

If the CSF pressure is less than or greater than normal 90-180 mmHg, what is the volume to be collected/ used

A

only 1-2 ml is used

23
Q

If the CSF pressure is greater than 200 mmHg, what is the volume to be collected/ used

A

not more than 2 mL

24
Q

Normal CSF volume for:
Adults
Neonates

A

90-150 mL
10-60 mL

25
Tube distribution should be:
1. Chem/IS 2. Microbio 3. Hema/ Cytology studies 4. Microbio or Sero
26
In tube distribution, what is the storage temp of Chem/ IS
Freezer temp
27
In tube distribution, Microbiology is for ____, what is the storage temp
better, exclude skin contamination Room temp
28
In tube distribution, Hematology is for _____, and what is the storage temp
cell count Ref temp
29
Tube distribution if there is 1 tube only
Microbiology, Hematology, Chem/Sero
30
T/F Excess CSF should be discarded after
FALSE should not be discarded and should be frozen until there is no further use of it.
31
Appearance of a Normal CSF
Crystal clear
32
- Increase WBC that is greater than 200 /ul - Increase RBC that is greater than 400/ ul - Presence of microorganism - Increase Proteins and Lipid
Hazy, Cloudy, Turbid, Milky
33
Pink: Slight amount of oxyhemoglobin Yellow: bilirubin traces Orange: In case of heavy hemolysis Brownish: methemoglobin formation
Xanthochromic (Reddish to pinkish)
34
- Increase dietary carotene - Increase rifampin intake - Increase melanin - Normal neonate - Protein concentration exceeding 150mg/dL - Previous traumatic tap
Xanthochromic (Reddish to pinkish)
35
Greater than 6000 RBCs/ul due to: - Traumatic tap or - Intracranial hemorrhage/cerebral hemorrhage
Bloody / grossly bloody
36
Radiographic contrast dye
Oily
37
Protein and clotting factors Meningitis, Froin’s syndrome
Clotted
38
Tubercular meningitis
Pellicle
39
Distribution of blood in 3 tubes in Traumatic tap
1>2>3
40
Clot formation in Traumatic tap
Presence of clot
41
Supernatant in Traumatic tap
Clear
42
Erythrophages in Traumatic tap
Absent
43
D-dimer test in Traumatic tap
Negative
44
Distribution of blood in 3 tubes in Intracranial hemorrhage
1=2=3
45
Clot formation in Intracranial hemorrhage
No clot formation
46
Supernatant in Intracranial hemorrhage
After 2 hrs it will be Xanthochromic
47
Erythrophages in Intracranial hemorrhage
Present
48
D-dimer test in Intracranial hemorrhage
Positive