CS: PUPD Flashcards
how can repro be linked to PUPD?
Diestrus can pdf diabetes (don’t know why?)
Ddx for a FE bithc, PUPD and off colour with small amammary mass?
- Pyo
- Kidney dz (pyelonephritis)
- mammary neoplasia
- Diabetes insipidus
- Hyperadrenocorticism
- 1* psychogenic PD
- liver dz
- hypercalcaemia
What ddx can urinalysis definitely prove/disprove on its own?
Diabetes (but still useful for others)
- expect low USG because PU
Should mammary masses be FNAd?
NO! Excisional biopsy
- all other masses should be FNA’d
What are the subcategories of 1* polyuria?
> osmotic - DM > interference with ADH-R - pyometra (bacterial endotoxins) - hyperCa - 1*/2* nephrogenic diabetes insipidus (conceptiually can be a 1* problem with the kidney, in reality always 2* to other causes) > ADH production - central diabetes insipidus > lack of medullary hypertonicity - liver dz (v urea, hypokalaemia can -> 2* nephroenic DI ) - Addisons (v Aldosterone so Na lost) - CKD (loss of pumps to make the gradient)
Which neopasa most commonly causes hyper calceamia?
Anal sac carcinoma
How can central diabetes insipidus be diagnosed?
Desmopressin injection test responsive (cf. nephrogenic where would not respond)
- complete and partial (if dehydrated can concentrate a bit)
How can true hypercaccemia be dx if albumin is also ^?
check ionised Ca
Will pyelonephritis always be seen with changes on bloods?
No only 1/3
Causes of 1* polydipsia?
> hyperadrencorticism
- cortisol inhibits ADH and ^ blood flow to kidney
psychogenic
- 1/2 (hepatic encephalopathy)
How are other signs of Cushings caused?
- Cortisol…
- inhibits anagen (-> alopecia)
- protein catabolism -> induced diabetic state IN SOME CASES ONLY
- lipolysis -> hyperlipaemia and pot belly
3 types of hyperadrenocorticism?
- Iatrogenic
- Adrenl dependant
- Pituitary dependant
