Crohns/UC

Question 1

Cause of Crohns Disease

Answer 1

Autoimmune - Chronic inflammation w remission & exacerbation

o No known cause- genetic/environmental (antigen thought to stimulate inflammation)

Question 2

Crohns Population

Answer 2

White teens / early adult

Question 3

Symptoms of Crohns

Answer 3

Diarrhea w blood, 
wt loss, 
abd pain, f
fever/fatigue, 
colicky pain
Mimic appendicitis

Question 4

Where does Crohns occur in bowel?

Answer 4

Common in terminal ileum/colon, can occur anywhere

Question 5

Crohns effect on intestines

Answer 5

Cobblestone/skip lesions,
normal segments of bowel,
deep longitudinal lesions

Question 6

Risks associated w Crohns

Answer 6

Fistula

Peritonitis

Question 7

DX of Crohns

Answer 7

Stool culture, 
CBC, 
lytes, 
biocarb Mg, 
albumin, 
radiology/capsule endo, Nutrition/drug/surgical therapy (75%)

Question 8

Drugs for Crohns Disease

Answer 8

5-aminosalicytics, 
antimicrobials, 
corticosteroids, 
immunosuppressant’s, 
bio therapy, 
anti-diarrheal, 
iron + vit.

Question 9

Cause of Ulcerative Colitis

Answer 9

Autoimmune - Chronic inflammation w remission & exacerbation

No known cause- genetic/environmental (antigen thought to stimulate inflammation)

Question 10

Population of Ulcerative Colitis

Answer 10

Common in white teens & early adults

Question 11

Symptoms of Ulcerative Colitis

Answer 11

Diarrhea w blood, 
wt loss, 
abd pain,
fever/fatigue, 
colick pain

Question 12

Where does Ulcerative Colitis occur in bowel?

Answer 12

Starts in rectum moves to cecum- disease of rectum and colon

DOES NOT EXTEND THROUGH BOWEL WALL- MUCOSA ONLY

Question 13

Risks of Ulcerative Colitis

Answer 13

Damage to mucosa epithelium = diarrhea

FISTULAS / ABSCESS RARE

Question 14

Mild Pain associated with Ulcerative Colitis

Answer 14

1-2 semi formed stools w blood

Question 15

Moderate Pain associated with Ulcerative Colitis

Answer 15

4-5 stools/day w bleeding and systemic symptoms

Question 16

Severe Pain associated with Ulcerative Colitis

Answer 16

10-20 bloody stools/day fever wt loss >10% tbw, anemia, tachy

Question 17

Complications of Irritable Bowel Disease

Answer 17

Hemorrhage, 
strictures, 
perforation, 
fistula, 
toxic megacolon, 
nutritional def., 
risk of cancer

Question 18

Systemic Complications of IBD:

Answer 18

Arthritis, 
eye inflammation,
 skin lesions d/t cytokines, 
thromboembolism, 
kidney stones, 
scleorosing cholangitis,
 gallstones

Question 19

drug therapy for IBD

Answer 19

5-Aminosalictates- Direase GI inflammation through direct contact w mucosa
Sulfasalazine
Mesalamine
Olsalazine
5-asa enema
Mesalamine suppositories

Question 20

Corticorsteroids for IBD

Answer 20

decrease inflammation

Systemic (prednisone, budesonide, hydrocortisone, ethylpredinosone)

Question 21

Antimicrobial for IBD

Answer 21

flagyl,
cypro,
biaxin

Topical (Hydrocortisone suppository or foam or enema)

Question 22

Immunosuppressant’s for IBD

Answer 22

-azathioprine,
6-mp,
cyclosprine

Question 23

Biologic therapy for IBD

Answer 23

Infliximab

Question 24

Anti Diarrheal for IBD

Answer 24

diphenoxylate w atropine,

lopermadine (immodium)

Question 25

Hematinic and vitamins for IBD-

Answer 25

iron,
zinc,
folate