Crohns/UC Flashcards
Cause of Crohns Disease
Autoimmune - Chronic inflammation w remission & exacerbation
o No known cause- genetic/environmental (antigen thought to stimulate inflammation)
Crohns Population
White teens / early adult
Symptoms of Crohns
Diarrhea w blood, wt loss, abd pain, f fever/fatigue, colicky pain Mimic appendicitis
Where does Crohns occur in bowel?
Common in terminal ileum/colon, can occur anywhere
Crohns effect on intestines
Cobblestone/skip lesions,
normal segments of bowel,
deep longitudinal lesions
Risks associated w Crohns
Fistula
Peritonitis
DX of Crohns
Stool culture, CBC, lytes, biocarb Mg, albumin, radiology/capsule endo, Nutrition/drug/surgical therapy (75%)
Drugs for Crohns Disease
5-aminosalicytics, antimicrobials, corticosteroids, immunosuppressant’s, bio therapy, anti-diarrheal, iron + vit.
Cause of Ulcerative Colitis
Autoimmune - Chronic inflammation w remission & exacerbation
No known cause- genetic/environmental (antigen thought to stimulate inflammation)
Population of Ulcerative Colitis
Common in white teens & early adults
Symptoms of Ulcerative Colitis
Diarrhea w blood, wt loss, abd pain, fever/fatigue, colick pain
Where does Ulcerative Colitis occur in bowel?
Starts in rectum moves to cecum- disease of rectum and colon
DOES NOT EXTEND THROUGH BOWEL WALL- MUCOSA ONLY
Risks of Ulcerative Colitis
Damage to mucosa epithelium = diarrhea
FISTULAS / ABSCESS RARE
Mild Pain associated with Ulcerative Colitis
1-2 semi formed stools w blood
Moderate Pain associated with Ulcerative Colitis
4-5 stools/day w bleeding and systemic symptoms
Severe Pain associated with Ulcerative Colitis
10-20 bloody stools/day fever wt loss >10% tbw, anemia, tachy
Complications of Irritable Bowel Disease
Hemorrhage, strictures, perforation, fistula, toxic megacolon, nutritional def., risk of cancer
Systemic Complications of IBD:
Arthritis, eye inflammation, skin lesions d/t cytokines, thromboembolism, kidney stones, scleorosing cholangitis, gallstones
drug therapy for IBD
5-Aminosalictates- Direase GI inflammation through direct contact w mucosa Sulfasalazine Mesalamine Olsalazine 5-asa enema Mesalamine suppositories
Corticorsteroids for IBD
decrease inflammation
Systemic (prednisone, budesonide, hydrocortisone, ethylpredinosone)
Antimicrobial for IBD
flagyl,
cypro,
biaxin
Topical (Hydrocortisone suppository or foam or enema)
Immunosuppressant’s for IBD
-azathioprine,
6-mp,
cyclosprine
Biologic therapy for IBD
Infliximab
Anti Diarrheal for IBD
diphenoxylate w atropine,
lopermadine (immodium)
