Crohns Flashcards
Where does the pathology of Crohns extend to
mouth–> Anus
4 Areas of pathology:
-Pancolitis
-Skip lesions (so the lesion skips certain parts and is not continuous)
-Terminal Ileum (Commonly involved= Key)
Ileocolonic (Ascending partof colon)
Most common symptoms (happens in 90% patients)
- Intermittent abdominal pain,
- Diarrhea
- Abodominal distention
3 Phenotypes in Crohns
Stricturing
Penetrating
Non penetrating
What happens in Strictured Crohns
Thickened intestinal wall –> Stenosis
What happens in penetrating Crohns
- Internal fistula between GI tract + other organs
- External Fistula between GI tract+ Skin
What happens in Non penetrating Crohns
- Anal fissure
- Abcess
8 Macroscopic Changes in Crohns
- Thickened Bowel
- Narrow lumen
- Deep Ulcer
- Apthoid Ulcer
- Abcess
- Fistulae
- Mucosal Fissure
- Cobblestones
4 ways to diagnose Crohns
Sigmoidoscopy, Barium Enema, Biopsy and Colonoscopy
What shows up on a Barium Enema
Rose thorn lesions, Skip lesions
Differential diagnoses of Crohns:
TB and Sarcoidosis
Specific Dental issues linked to Crohns
Cobblestoning, Mucosal Tags, Labial/Buccal swelling, Ulceration, mucogingitivis, Granulomatous Chelitis
Non specific dental issues linked to Crohns
Apthous Ulcers, Angular Chelitis, Caries, Periodontal disease, Glossitis
4 other symptoms linked to crohns
Arthopathy, Back pain, B12 deficiency–> Anaemia, gallstones
What are the 4 types of drugs used to treat crohns and give examples
Glucocorticoids: Prednisolone
Immunomodulator: Mesalazine
Biologics: Humera
Imunnosuppreseant: Cyclosporin
