Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Exam 3 > Crohn's & Ulcerative Colitis > Flashcards

Crohn's & Ulcerative Colitis Flashcards

1
Q

Compare C and UC population

A

C: 20-30
UC: bimodal 20-30, 50-75

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

C vs UC endoscopy findings

A

C: skin lesions anywhere in GI tract, cobblestone appearance
UC: continuous starting at rectum, but stays in colon, pseudopolyps and chronic colitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

C vs. UC intestinal inflammation

A

C: transmural, non caseating, granulomas more common
UC: superficial, crypt abscess, backwash ileitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

UC barium enema shows

A

Loss of haustral markings, thumbprint

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

C vs UC diarrhea

A

C: watery, weight loss
UC: bloody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which IBD has increased risk of CRC?

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Extraintestinal manifestations of IBD

A

OAT LARDS!

Ocular: iritis, uveitis, episcleritis
Arthritis, arthralgias
Thromboembolic disease

Liver disease
Amyloidosis
Renal disease: UTI, stones, obstruction, fistulae
Dermatologic: erythema nodosum, pyoderma gangrenous, aphthous ulcers
Sclerosing cholangitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Curative treatment for UC? Why is it not curative for crohn’s?

A

Colectomy is curative

If you remove GI tract in crohn’s, disease may recur elsewhere in the GI tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

UC Complications

A
  1. Severe bleeding- urgent colectomy indicated
  2. Toxic Megacolon- acute dilation of the colon due to involvement of the muscular layers. Urgent colectomy.
  3. Perforation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Terminal ileum resected, what am I having issues with now?

A

B12, fat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Duodenum resected, what am i having problems with now?

A

Fe, osteopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

While IBD causes is unknown, it may be linked to what?

A

Bacteria
Microbiome
Genetics
Virus, worm, parasite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

UC colonic features

A 
Bloody mucus, diarrhea
Tenesmus
Frequency, urgency, incontinence
Rectal bleeding
Abdominal pain
Fever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What bacterial infection do IBD patients get?

A

C diff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Mesalamine (5-ASA) MOA

A

Inhibits lipoxygenase:

  1. Decreases leukotrienes
  2. Remove oxygen free radicals
  3. Inhibits auto Ab formation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

First line therapy for mild to moderate IBD

A

5-ASA Mesalamine

17
Q

What is the multi-matrix system mesalamine (MMX)?

A

Combines a pH dependent coating with mesalamine to delay release of medication to colon

18
Q

When would I give steroids for IBD?

A

Induce remission during flare up, but for 6 months or less only

19
Q

Side effects of prednisone

A 
Weight gain
Insomnia
DM
HTN
Osteoporosis
20
Q

6-MP/AZA MOA

A

Immunosuppressant inhibits purine synthesis necessary for lymphocyte proliferation

21
Q

What drug helps fistula closure and prevents post op recurrence of IBD?

A

6-MP/AZA

22
Q

Anti-TNF drugs for IBD

A

Infliximab- Remicade
Adalimumab- Humira
Certolizumab- Cimzia

23
Q

What kind of cytokine is lacking in IBD?

A

Anti- inflammatory

24
Q

UC pathology

A 
Crypt abscess and crypt branching
Eroding ulceration
Pseudopolyps
Granulomas
Backwash ileitis
25
Q

Which IBD can develop into another?

A

UC and develop into Crohn’s but not the other way around

26
Q

Bowel to bowel fistula

A

Enteroenteral

Enterocolic

27
Q

Bowel to bladder fistula

A

Enterovesical

28
Q

Bowel to vagina fistula

A

Rectovaginal

29
Q

Enterocutaneous fisuta

A

Perinatal or through the abdominal wall

30
Q

Fecal study for inflammation

A

Fecal calprotectin

Measures WBC breakdown, inflammation in GI tract

31
Q 
Drug location targets for mesalamine:
Asacol
Pentasa 
Colazal
Canasa
A

Asacol- colon
Pentasa - small intestine
Colazal- colon
Canasa- rectal

32
Q

Mesalamine side effect

A

Split causes Cl secreation and induces diarrhea

33
Q

Antibiotics indicated for IBD

A

Cipro

MTZ

34
Q

What. Nutritional deficiency do you watch out for in IBD?

A 
Calcium- if patient avoids lactose in diet
Vitamin D
Vitamin B12- ileum resection
Folate- jejunal resection
Iron- blood loss
35
Q

IBD diet

A

Lactose free
Low fiber
Elemental
Probiotic

36
Q

Side effects of anti-TNF

A 
Infection: Tb, histoplasmosis
HA
Abd pain
Immunogenicity
Obstruction
Lymphoma

Exam 3 (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions