Crohn's disease

Question 1

what are the 2 causes of idiopathic inflammatory bowel disease (IBD)?

Answer 1

Crohn’s disease and ulcerative colitis

Question 2

when is the peak onset of IBD?

Answer 2

15-30 years old

Question 3

what increases risk of crohn’s disease?

Answer 3

smoking

Question 4

which disease always affects the illeum and colon?

Answer 4

Crohn’s disease

Question 5

what disease always includes the rectum and almost always the colon?

Answer 5

`ulcerative colitis

Question 6

what disease is continuous within the colon?

Answer 6

ulcerative colitis

Question 7

what disease is discontinuous in the GI tract?

Answer 7

Crohn’s disease

Question 8

which disease is hematochezia common?

Answer 8

ulcerative colitis

Question 9

which disease rarely has intestinal granulomas, strictures, and fistulas?

Answer 9

ulcerative colitis

Question 10

which disease includes the upper GI tract?

Answer 10

Crohn’s

Question 11

What type of inflammation is present in Crohn’s disease?

Answer 11

transmural

Question 12

what type of inflammation is present in ulcerative colitis?

Answer 12

mucosal

Question 13

what percentage of patients show extra-intestinal manifestations?

Answer 13

25%

Question 14

what is the etiology of IBD?

Answer 14

inappropriate inflammatory response to intestinal microbes in a genetically susceptible host

Question 15

what are the genetic factors related to IBD?

Answer 15

1. nucleotide oligomerization domain 2 (NOD2)
2. interleukin-23-type 17 helper T-cell (Th17) pathway
3. autophagy genes

Question 16

what are 4 causes of rising prevalence of IBD?

Answer 16

1. changes in diet
2. antibiotic use
3. altered intestinal colonization
4. tobacco