Critical Care Flashcards
How do you calculate Cerebral Perfusion Pressure?
CPP = MAP - ICP = (2/3 DBP + 1/3 PP) - ICP
Hypoxia causes _______ of cerebrovasculature.
vasodilation
Hypotension leads to _________ of cerebrovasculature.
Vasodilation (therefore increased ICP)
What defines a supraventricular tachycardia on EKG?
Rate > 100 w/ a QRS < 0.12
Multifocal atrial tachycardia is associated with what disease processes?
COPD and Theophylline use
What is the most common reentrant accessory pathway in AV reentrant tachycardia? What is the EKG characteristic? In what disease processes can it be seen?
Bundle of KentDelta wavesWolff-Parkinson-White syndrome
What two electrolyte abnormalities are associated with ventricular tachycardia and polymorphic tachycardia?
hypokalemia and hyponmagnesia
What EKG findings are seen in digoxin use?
gradual downward curve of the ST segment (causes multiple dysrhythmias and AV block)
What EKG findings are seen in hypocalcemia?
increased QT interval
What EKG findings are seen in hypothermia?
J-point elevation
What EKG changes are seen in Brugada syndrome?
right BBB w/ ST eelvation in V1-3
predsiposes to sudden cardiac death
What EKG changes are seen in SAH?
peaked T waves and ST depression
What are the classes of Antiarrythmics?
Class 1 (Na Channel blockers)
Class 2 (B blockers)
Class 3 (K channel blockers)
Class 4 (Ca channel blockers)
Stimulation of Andrenergic Alpha Receptors leads to ______.
vasoconstriction
Stimulation of Andrenergic Beta-1 receptors leads to ______.
increases cardiac output (chronotropy) and strength of contraction (inotropy)
Stimulation of Andrenergic B-2 Receptors leads to ______..
vasodilation
Activation of dopamine receptors causes ______ of cerebral, renal, coronary, and mesenteric vasculature.
vasodilation
What receptors does dobutamine acitvate?
B1 agonist, mild B2 and A2 agonist
What are the effects of dobutamine?
inotropic, peripheral vascular dilation, increases cardiac output, decrease in SVR
No change in BP
side effect of tachycardia
At low doses, dopamine causes _______ while at high doses it causes ________.
vasodilation; vasoconstriction
Phenylephrine affects predominantly _____ receptors.
alpha 1
What kind of pressor is vasopressin?
norandrenergic
What are contraindications for norepinephrine use?
renal failure
What electrolyte abnormality enhances digoxin toxicity?
hypokalemia
When therapeutic, what are the effects of digoxin?
AV and SA node conduction slowing
What are the treatments for digoxin toxicity?
K, Mg, Lidocaine, Digoxin antibody, and charcoal
What are the cardiovascular effects of furosemide?
increases SVR and decreases CO
What medication can block the response of furosemide?
NSAIDs
What are the major side effects of furosemide?
ototoxicity, hypokalemia, hypomagnesemia, hypochloremia, and metabolic alkalosis
What receptors does labetalol act upon? What are its effects?
alpha and beta receptors; lowers BP but does not increase HR or increase CO
What is the treatment for methemoglobinemia? What cardiac drug can cause methemoglobinemia?
Methylene blue
Nitroglycerine
What cardiac drug can cause cyanide toxicity?
Sodium nitroprusside
What are the treatments for air embolism?
left lateral decubitus position, hyperbaric oxygen, or removal of air embolism
Describe the Bohr effect. What causes respective right and left shifts?
changes in the oxygen dissociation curve to either facilitate oxygen absorption or bonding with hemoglobin.
Right: tissues with decreased oxygen affinity
- increases in acidity
- CO2- temperature
- 2,3-DPG
Left: lung, increased affinity for oxygen
- opposite as above
What is characteristic of ARDS on BAL?
high protein levels
B2 agonists have what affect on the respiratory system? What are their potential side effects?
bronchodilators
at high doses can cause tachycardia, hypokalemia, or tremors
What is the mechanism of theophylline?
increase cAMP
Inhaled anticholinergics include ______ and ______. They cause _______ .
Atropine and Ipratropium
decreased parasympathetic input (decreased bronchoconstriction)
What is the duration of vecuronium?
30 minutes
What is the duration of pancuronium?
1 hour
Succinylcholine is what type of paralytic? What electrolyte abnormality can it cause?
depolarizing blocker
hyperkalemia
What is normal tidal volume in adults?
5-6 cc/kg
What urine casts are seen in Prerenal conditions?
hyaline and finely granular casts
What urine casts are seen in Acute Tubular Necrosis?
epithileal and course granular casts
What urine cases are seen in Acute Interstitiial nephritis?
white cell casts
What urine cases are seen in Acute Glomerulonephritis?
red cell casts
When should dialysis be considered in acute renal failure?
K > 6.5, blood pH < 7.1, refractory hypovolemia w/ BUN > 80, Na < 120 or > 155, or overdose of dialyzable drug
Which of the renal tubular acidosis have hyerkalemia and which have hypokalemia?
Hyperkalemia: RTA 4
Hypokalemia: RTA 1 and 2
Where do loop diuretics act upon? What is the mechanism?
ascending limb of loop of henley
prevent sodium absorption by interfering with Na-K-Cl pump
What is the mechanism of thiazide diuretics?
inhibit Na-Cl cotransporter
What are examples of K sparing diuretics? Where do they act?
Amiloride, spironolacotone
cortical collecting tubules