Craniofacial Bone Complex and Joints Flashcards

1
Q

Human Skeleton

About 270 bones at birth Reduced to 206 by Adulthood

Axial Bones
Skull: _____ bones plus _____ associated bones
Torso: 52 bones

Appendicular bones
Upper extremities: 64 bones Lower extremities:62 bones

A

22

9

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2
Q

The Skull
_____: The region of the skull that encases the brain

_____:
The region of the skull that makes up the bones of the face

A

neurocranium

vicerocranium

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3
Q

Neurocranium

Cranial _____:
The portion of the skull that overlies the brain; It is formed by _____ ossification

Cranial _____:
The portion which underlies the brain; It is formed through _____ ossification (_____)

A
vault
intramembranous
base
endochondral
chondrocranium
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4
Q

Membranous bones of the skull:

Membranous bones making up the calvarium of the skull are each derived from the _____ ossification center.

how membranous bones develop

week _____: bony spicules, ossification centers grow outward and then they meet; the area where they meet never really _____ > develops into the cranial _____

occipital, parietal, frontal, maxilla, mandible, nasal bone

A

primary
6-7
ossifies
sutures

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5
Q

Development of Cranial base: Chondrocranium

Cartilaginous precursors of the cranial base, several small cartilages form a central stem and other cartilages outline paired lateral structures, begin to appear at about _____ weeks of development in the mesoderm or ectomesenchyme separating the brain above from the rest.

The chondrocranium is fully fused and differentiated by the end of the _____ month of pregnancy, or _____ weeks since the initiation of cartilage formation.

Mineralization of the chondrocranium takes place at various centres of
ossification that appear in the cartilages of the cranial base

A

7
second
2

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6
Q

Alveolar process of maxilla

alveolar process - teeth are embedded; different from the rest of bone, develops in a different _____; present only when teeth are present, when no teeth > it _____ and _____

A

manner
regresses
disappears

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7
Q

Prenatal Growth and Development of Maxilla:

  • Maxilla forms within the maxillary _____ extending ventrally from the _____ arch
  • _____ ossification
  • Ossification starts in _____ week
  • _____ development

mandibular arch is the _____ brachial arch > has a maxillary process that extends and forms the upper face; ossification begins here

brachial arch is _____ (maxilla is derived from neural crest)

A
prominences
mandibular
intramembranous
7th
palatal

first
neural crest

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8
Q

Postnatal Growth and Development :

Two Basic Modes of Growth Movements

  1. Remodeling:
    Deposition and resorption of bone
    (a) _____
    (b) _____
  2. Displacement:
    Growth movements which cause separation of the different bones
    (a) _____
    (b) Cranial base _____
A

cortical drift
relocation

sutural growth
synchondrosis

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9
Q

Postnatal Growth and Development

intramembranous > bone is added on the surface, only grows by _____ growth

as you go from immature to mature bone; you must ____ (cortical drift/relocation)

A

appositional

remodel

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10
Q

Remodeling and Relocation vs. Cortical Drift

EXPLAIN ME

A

YES

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11
Q

Remodeling of Palate

ü Bone ____ on oral side
ü Bone ____ on nasal side

A

deposition

resorption

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12
Q

know that the maxilla (maxillary tuberosity, alveolar processes) grows via a ____ process

A

remodeling

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13
Q

Mandible

mandibular notch, when condyle is absorbed in arthritis, you will see changes in the mandibular ____

A

notch

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14
Q

Mandible: Prenatal Growth & Development

  • ____ week in uterine
  • ____ & ____ ossification
A

6th
intramembranous
endochondral

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15
Q

Body:
The mandible is ossified in the fibrous membrane covering the outer surfaces of ____ (6th wk)

meckel’s cartilage forms the original ____, but never turns into the mandible; serves strictly as the ____ structure; formed by ____ ossification

A

meckel’s cartilages
temple
positioning
intramembranous

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16
Q

Ramus:

The condylar cartilage - Carrot shaped cartilage appears (____ wk) in the region of the condyle and occupies most of the developing ramus. Converts to bone by ____ ossification (____ wk), forming condyle head and neck.

Coronoid process - A small strip of cartilage appears along the anterior border of the coronoid process. It is invaded by the surrounding membrane bone and undergo absorption (____ wk).

condylar cartilage is maintained until ____; cartilage in coronoid process ____

A

10th
endochondral
14th

10-14th

puberty
regresses

17
Q

Alveolar Bone

It starts when the deciduous tooth germs reach the early ____ stage. The bone of the mandible begins to grow on each side of the tooth germ.

The alveolar processes grow at a rapid rate during the periods of ____.

A

bell

tooth eruption

18
Q

Mandible: Postnatal Growth & Development
Main Growth Sites:
ü Secondary Cartilage (____ Cartilage)
ü ____ Ridge
ü The Ramus
ü Lingual ____

A

condylar
alveolar
tuberosity

19
Q
  1. Condylar Cartilage:
    • ____ cartilage
    • Functions as ____ cartilage and ____ site (which is why it is formed by both intra/endo ossification).
    • Adoptive response to mechanical ____ and development
    • Growth of condylar cartilage helps in:
    - Increase in ____ of the mandibular ramus
    - Increase in the overall ____ of the mandible
    - Increase of the inter condylar distance (____)
  2. Growth with the alveolar process:
    • Due to the increase in the space between the upper and lower jaws a space created between the opposing teeth to erupt. This means that bone deposition contributes to the growth of the body of the mandible in ____.
A
secondary
articular
growth
stress
height
length
width

height

20
Q
  1. Ramus:

Periosteal bone apposition and resorption (bone remodeling) help in mandible growth. The results depend on the place of bone remodeling. Growth can occur in ____, ____ and ____

Move posteriorly by bone deposition on ____ border and resorption on ____ border. The anterior part of the ramus becomes the ____

A

height
length
width

posterior
anterior
corpus

21
Q

Width
Completed before ____ growth spurt at around age ____

Length
Continues through puberty
- Girls: ____ years
- Boys: ____ years

Height
Continues into ____ after the growth spurt

large mandible > jaw surgery > you want it to be passed the time of length completion (girls for 16, boys closer for 20)

height growth until adulthood becomes a problem for placing dental implant in teenagers (18 y.o.); the dental implant will still behind, nowadays implants are placed much later on (girls 20, boys even later)

A

adolescent
12

14-15
18-19

adult

22
Q

Jaw Alignment

Class I = ____
Class II = ____
Class III = ____

class III > if overgrown mandible, postpone surgery because mandible continues to grow until later in life (bc has it’s own growth potential)

A

balanced jaw relationship
underdeveloped mandible
overgrown mandible/underdeveloped maxilla

23
Q
JOINTS in the SKULL
•  \_\_\_\_ 
•  Sutures
•  \_\_\_\_ 
•  Gomphosis

TMJ is not identical to other synovial joints in the body; synovial joints in the skull are ____

not unique joint structure in skull > synchondroses/sutures (____ and ____ are unique in skull)

A

synchondroses
synovial joint

unique

synovial joints
gomphosis

24
Q

Synchondrosis

  • A union between two bones by the formation of either ____ cartilage or ____ cartilage
  • Usually ____ and exists during the growing phase until the intervening cartilage becomes progressively ____ and ultimately becomes obliterated and converted into bone before adult life
A

hyaline
fibro
temporary
thinner

25
Midline Synchondroses of Cranial Base Important ____ for the skull Spheno-ethmoid Synchondrosis closes at ____ Intersphenoid Synchondrosis ossifies at ____ Spheno-occipital synchondro closes between age ____ intersphenoid synchondrosis very little ____ contribution orthodontists love the ____ synchondrosis; cannot manipulate cartilage
growth center age 6 birth 13-15 post-natal spheno-occipital
26
Epiphyseal growth plate of long bones: Resting/Proliferating/Hypertrophic Synchondrosis Hypertrophic/Prolif/Resting /Prolif/Hypertrophic REWATCH ME
HALLO
27
Cranial Base Synchondroses are Important “Growth Center” Ex vivo explant experiment showed that spehnoid-occipital synchondrosis can enlarge independently without ____ factors. Cranial base synchondroses are regarded as important growth centers of the craniofacial skeleton, particularly the ____ synchondrosis because of its late ossification and important contribution to post-natal cranial base growth has intrinsic potential to how much it grows; ____ programmed Timing of Closure: • Spheno-ethmoid S: ____ yrs • Interspenoidal S: at ____ • Spheno-occipital S: ____ yrs
``` extrinsic spheno-occipital 6 birth 13-15 ```
28
Abnormal Development of the Cranial Base: * ____ (Apert, Crouzon, Pfeiffer) * Down’s syndrome * ____ syndrome * Klinefelter syndrome * ____ syndrome * Achondroplasia Premature growth arrest of the cranial base leads to midface ____ and reduced midfacial ____
``` syndromic craniosynostosis turner william's retrusion height ```
29
Premature Closure of the Cranial Base - ____ distraction osteogenesis
Lefort II
30
Temporomandibular Joint (TMJ) * The only movable ____ in the head that connects the mandible to the rest of the skull * One of the most used joints in the body * Biting force, ____ lbs/in2
synovial joint | 600-1000
31
TMJ movement only when open a half inch = ____ movement when you open more; the disc and the joint slides forward; ____ movement > exerts a lot of stress to the joint; which is protected by the ____
roll translational articular disc
32
TMJ movement when closed; disc sits right on top; when you open the disc moves with the condyle; protects the condyle, the tip of condyle is thin articular cartilage so it requires protection when abnormal; disc is ____ displaced; ____ stage, the condyle moves so the disc gets placed back on top of the condyle or it can be totally ____ so the disc does not return to the top of the condyle; when this continues > ____ treatment > remove the disc, or pull the disc back over top of the condyle Osteoarthritis • Surface ____ • Perforation of ____ • Fibrous ____
anteriorally early locked osteoarthritis erosion disc adhesion
33
``` Joint Lubricants in TMJ:  • ____ • ____ • Surface Active Phospholipids ``` Lack of lubrication > increased ____ > adhesion, displacement, ____, distortion of the articular disc > degenerative arthritic change
lubricin hyaluronate (HA) friction hypertropy
34
The effect of loss of Lubricin function in PRG4 knock out mouse TMJ Lubricin has ____ and ____ activities PRG4 makes ____; when KO the gene, the disc becomes ____, and the increase of protein deposit on the ____ chamber, and the disc changes its properties after 3 months, ____ of the surface and ____ of the disc
anti-adhesion anti-cell growth lubricin thick upper erosion adhesion
35
HA-deficient TMJ in Has2f/f;Aggrecan CreERT2 Has2f is the enzyme that makes ____, when KO the join starts to change in appearance, the cartilage looks VERY ____ really ____ cells on top of the cartilage, cracking of the cartilage surface, it is clearly an arthritic joint proves that we need enough lubricant for proper TMJ function
hyaluronate (HA) different proliferating
36
``` TMJ Disorder (TMD): • A group of conditions that cause pain in the jaw joint and muscles, noises (clicking or crepitus) and restricted jaw movement. • 10-30 million people/year in US, (F:M = ____) Causes: - Trauma - Rheumatoid arthritis - Psycosocial – stress - Parafunctional activities, ____ - ____ factor - Systemic joint ____ - Unknown ```
2:1 bruxism occlusal laxity (flexible joint)
37
TMJ and Facial Development Abnormal facial development is observed in patients with • Trauma to TMJ • Developmental malformation of the ____ • ____ Juvenile idiopathic rheumatoid arthritis: • ____ in age between 0-15 yrs; this number is actually under-estimated, in reality it is much higher • Reports on TMJ involvement in JIA varies between 40-70% • TMJ erosion is often associated with ____ • ____ joint in JIA • Early ____ is necessary to prevent severe damage to the TMJ and its consequences.
mandibular condyle juvenile idiopathic rheumatoid arthritis (JIA) 1-1000 no pain under-diagnosed detection
38
TMJ and Facial Development * ____ * Limited mouth opening * ____ dysfunction * Occlusal cant/Facial asymmetry * ____ * Breathing problem: ____
micrognathia (mandible) jaw muscle open bite obstructive sleep apnea (OSA)
39
Missing/smaller condyle? Suggestive of ____
arthritic TMJ