CPT Drugs List - Nervous System Flashcards
Anxiolytics
(Reduce anxiety)
Diazepam, Lorazepam, Midazolam
Increase GABA activity (inhibitory neurotransmitter)
Drugs for nausea and vomiting
H1 antagonists - Cyclizine
D2 antagonist - Domperidone, Metoclopramide (5HT3 antagonism also)
5HT3 antagonists - Ondansetron
Muscarinic antagonists - Hyoscine hydrobromide
Neurokinin-1 antagonists - Aprepitant
Antipsychotics
Chlorpromazine, Haloperidol
Primarily post synaptic D2 receptor antagonism – can be used as antiemetic agents
Analgesics
Aspirin - Prostaglandin production inhibition Paracetamol - In part, COX-2 inhibition in spinal cord
Buprenorphine, Codeine, Diamorphine, Fentanyl, Methadone, Morphine, Tramadol Opioid receptor agonists
Paracetamol overdose
Acetylcysteine
Glutathione donation
Opioid receptor antagonists
Naloxone
Partial antagonist, competes with opioids (e.g. buprenorphine/naloxone mixed tablet used to treat opioid use disorder)
Anti-epileptic
Carbamazepine, Lamotrigine, Phenytoin - Sodium channel blockers
Sodium Valproate - Many including indirect increase in GABA synthesis
Levetiracetam - Unclear, but presynaptic Ca2+ blocking activity in part
Types of drugs used in Parkinson’s disease
Dopamine receptor agonists
Monoamine oxidase type B inhibitors
Catechol-O-methyl transferase (COMT) inhibitors
Anticholinergics
Dopamine receptor agonists
Used in Parkinson’s disease
Amantadine, Apomorphine, Ropinirole, Rotigotine Levodopa (L-DOPA), Co-careldopa, Co-beneldopa Dopamine precursors
* - Contain levodopa and DOPA decarboxylase inhibitor
Monoamine oxidase type B inhibitors
Used in Parkinson’s disease
Rasagiline, Selegiline
Catechol-O-methyl transferase (COMT) inhibitors
Used in Parkinson’s disease
Entacapone
Anticholinergics
Used in Parkinson’s disease
Orphenadrine, Procyclidine
Acetylcholine inhibition
