CPT Drugs List - CVS

Question 1

Types of diuretics

Answer 1

Thiazides and thiazides like
Loop
Potassium sparing
Aldosterone antagonist

Question 2

Thiazides and thiazides like diuretics

Answer 2

Bendroflumethiazide, Indapamide

Inhibition of Na/Cl co-transporter in distal convoluted tubule

Question 3

Loop diuretics

Answer 3

Bumetanide, Furosemide

Inhibition of Na/K/2Cl co-transporter in the loop of Henle

Question 4

Potassium sparing diuretics

Answer 4

Amiloride

Block ENaC at the luminal surface of the renal tubule

Question 5

Aldosterone antagonist diuretics

Answer 5

Spironolactone

Compete with aldosterone at mineralocorticoid receptor

Question 6

Antiarrhythmics

Classes

Answer 6

Class I
Class II
Class III
Class IV
Unclassified

Question 7

Class I antiarrhythmics

Answer 7

Flecainide (1C), Lidocaine (1B)

Na channel blockers

Question 8

Class II antiarrhythmics

Answer 8

Bisoprolol, Metoprolol

Beta adrenoceptor blockers

Question 9

Class III antiarrhythmics

Answer 9

Amiodarone, Sotalol

Potassium channel blockers

Question 10

Class IV antiarrhythmics

Answer 10

Diltiazem, Verapamil

Calcium channel blockers

Question 11

Unclassified antiarrhythmics

Answer 11

Adenosine - Adenosine receptor agonist (A1 in SA and AV nodes)
Atropine - Muscarinic antagonist
Digoxin - Inhibition of Na/K-ATPase
Ivabradine - Inhibition of If current in SAN

Question 12

Beta adrenoceptor blockers

Answer 12

Atenolol, Labetalol, Propranolol

Question 13

Alpha adrenoceptor blockers

Answer 13

Doxazosin, (Tamsulosin)

Question 14

ACE inhibitors (ACEi)

Answer 14

Lisinopril, Ramipril

Inhibit angiotensin converting enzyme

Question 15

Angiotensin receptor blockers (ARB)

Answer 15

Candesartan, Losartan

AT1 receptor antagonist

Question 16

Nitrates

Answer 16

Glyceryl trinitrate, Isosorbide mononitrate

Soluble guanylyl cyclase activation - elevate cGMP - vasodilation

Question 17

Calcium channel blockers

Answer 17

Amlodipine, Diltazem, Nimodipine, Verapamil

Inhibition of L-type calcium channels - tissue selective

Question 18

Vitamin K antagonist

Answer 18

Warfarin

Vitamin K epoxide reductase inhibition

Question 19

Unfractionated heparin (UFH)

Answer 19

Heparin

Inhibition of active clotting factors - Xa and IIa (thrombin)

Question 20

LMWH

Answer 20

Dalteparin, Enoxaparin

Inhibition of active clotting factor Xa

Question 21

Synthetic (heparin) pentasaccharide

Answer 21

Fondaparinux

Inhibition of active clotting factor Xa

Question 22

Direct acting oral anticoagulants (DOACs)

Answer 22

Apixaban, Edoxaban, Rivaroxaban - inhibition of active clotting factor Xa
Dabigatran - inhibition of active clotting factor IIa (thrombin)

Question 23

Heparin reversal

Answer 23

Protamine Sulphate

Cationic peptide that binds to heparin forming inactive ion pair

Question 24

Warfarin reversal

Answer 24

Vitamin K1, Prothrombin complex concentrate

Promote production of clotting factors

Question 25

Antiplatelet agents

Answer 25

Aspirin - reduction of TXA2 synthesis by COX-1 inhibition
Dipyridamole - phosphodiesterase inhibitor and inhibition of adenosine Resp take in platelets
Clopidogrel, Prasugrel, Ticagrelor - ADP (P2Y12) receptor antagonists
Abciximab - irreversible binding of GPIIb/IIIa receptors

Question 26

Fibrinolytics

Answer 26

Alteplase, Streptokinase

Bind to and activate plasmin from plasminogen

Question 27

Antifibrinolytics

Answer 27

Tranexamic acid

Inhibit the activation of plasminogen from plasmin

Question 28

Types of lipid-lowering drugs

Answer 28

Statins
Fibrates
Cholesterol absorption inhibitors
PCSK9 inhibitors

Question 29

Statins

Answer 29

Atorvastatin, Simvastatin

Inhibit the rate limiting step of the mevalonate pathway (HMG-CoA reductase inhibitors)

Question 30

Fibrates

Answer 30

Fenofibrate

PPAR-alpha activator

Question 31

Cholesterol absorption inhibitors

Answer 31

Ezetimibe

NPC1L1 transporter inhibition

Question 32

PCSK9 inhibitors

Answer 32

Alirocumab

Monoclonal antibody that inhibits the PCSK9 enzyme