COVID 19

Question 1

Classification (full)

Answer 1

Coronaviridae, Betcoronavirus, Sarbecovirus, SARS

Question 2

Shape, genome and Baltimore and naked or enveloped?

Answer 2

Enveloped and Baltimore class IV
Genome→ positive sense single stranded RNAand non segmented
Spike protein → crown

Question 3

Pathogenesis?

Answer 3

Upper RT infected → replication
Alveoli → type II pneumocyte
ACE-2 receptor and spike protein
pneumocyte destroyed → viral release
Engulfed by alveolar macrophage → IL1 and TNF-a
Systemic hypotension → multi organ failure
causes SIRS

pneumocyte II → alveolar collapse
pneumocyte I → hypoxaemia

Question 4

Therapies of SARS COV 2 ?

Answer 4

Immunomodularts → Dexamethasone
RNA polymerase inhibitors → Remdesavir
Protease inhibitor → Paxlovid
Monoclonal → Sotrovimab

Question 5

Vaccines?

Answer 5

Inactivated vaccine
Protein based vaccine
viral vector
mRNA vaccine

Question 6

Examples of inactivated vaccines?

Answer 6

Covaxin
CoroVac

Question 7

Examples of protein based vaccines

Answer 7

Epivac
Nevavax

Question 8

Viral vectors (Adenovirus) ?

Answer 8

J and J

Question 9

mRNA vaccines

Answer 9

pfizer
Moderna

Question 10

Explain spike protein

Answer 10

S1→ receptor binding domain
S2→ fusion of virus with cell membrane