cough, cold, allergy Flashcards
What is the pathophysiology of cough
body’s protectionctive response to materials that irritate the respiratory tract, facilitating the removal of inhaled foreign particles and excessive secretions
stimulation of cough receptors along the airways –> signals to the cough control centre of the brain and back to the airway muscles to induce cough
name the antitussives (3)
dextromethorphan
codeine
pholcodine
Codeine and pholcodine MOA
decreases sensitivity of the cough receptors and interrupts the cough impulse transmission by suppressing the cough centres of the brain
codeine adult dosing
30mg tablet
0.5 to 1 tablet tds prn
codeine minimum age
12 yo
codeine SE
drowsiness and constipation
pholcodine SE
might be drowsy
dextromethorphan linctus peads dosing
2-5 yo: up to 2.5ml TDSprn
6-12yo: up to 5ml TDSPRN
> 12yo: up to 10ml TDSprn
dextromethorphan SE
may cause some drowsiness
pholcodine minimum age
reg: 2yo
forte: 12yo
dextromethorphan tablet adult dosage
1-2 tabs ads pro
list the expectorants (2)
diphenhydramine
guaifenesin
diphenhydramine class of drug
antihistamine (1st gen)
diphenhydramine MOA
irritative action on the thread –> causes the production of excess mucus and inducing cough
adult dose for diphenhydramine
10mg/5ml –> 10ml tdsprn
adult dose for guaifenesin
100mg/5ml: 12yo and above: up to 20ml tdsprn
kids dose for diphenhydramine
5mg/5ml: 2-5yo: 5ml
6-11 yo: 10ml tdsprn
kids dose of guaifenesin
100mg/5ml:
2-5yo: up to 5ml tdsprn
6-11yo: up to 10ml tdsprn
name mucolytics (3)
bromhexine (P or GSL)
acetylcysteine (P or GSL)
ambroxol (P or GSL for some)
acetylcysteine kids dosing
100mg sachet: 1 sachet bd-tdsprn
>6 yo: 2 sachet bd-tdsprn
acetylcysteine min age
2yo
acetylcysteine adult dosing
600mg effervescent tablet: 6yo and above 1 tab odprn
bromhexine kids dosing
4mg/5ml:
2-5yo: 2.5ml tdsprn
6-11yo: 5ml tdsprn
>12yo: 10ml tdsprn
bromhexine adult dosing
> 12yo: 1 tab tdsprn, max 48mg/day
bromhexine min age
2yo
why are mucolytics contraindicated in <2yo
increased risk of respiratory obstruction
ambroxol kids dosing
30mg/5ml:
2-5yo: 2.5ml tdsprn
6-11yo: 5ml bd-tdsprn
12yo and above: 10ml bdprn
ambroxol adult dosing
12yo and above 1 tab tdsprn up to 2 dabs bd prn
30 mg tablet