Cough Flashcards

1
Q

Describe a cough

A

A sudden, forceful release of air from the lungs

  • Reflex triggered by irritation or obstruction
  • Clears the lung passages via a rush of air
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2
Q

What is the cough reflex?

A

Step 1: Airway sensory nerves respond to pro-tussive stimulus
Step 2: Impulse travels along the VAGUS NERVE to the medulla
- The cough control center
Step 3: Medullary center sends message to respiratory pattern generator, eliciting cough response

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3
Q

Describe an Acute Cough:

A

Lasts less than 3 weeks

Usually associated with viral upper respiratory infections

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4
Q

List possible causes of acute cough.

A
  • Possibly pneumonia
  • Acute L ventricular failure due to stretching caused by fluid backing into lungs
  • Asthma
  • Foreign body aspiration
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5
Q

Describe a Subacute Cough:

A

Describe a Subacute Cough:
Lasts 3 to 8 weeks
- 3 to 4 weeks in kiddos

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6
Q

List possible causes of a subacute cough

A
  • Post-infectious cough
  • Bacterial sinusitis
  • Asthma
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7
Q

Describe a Chronic Cough:

A

Lasting over 8 weeks in adults

- >4 weeks in kiddos

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8
Q

List causes of a chronic cough in non-smokers:

A
  1. Upper Airway Cough Syndrome (UACS)
    - AKA Post Nasal Drip
  2. Asthma
  3. GERD due to acid irritation
  4. CHF
  5. Aspiration (commonly pneumonia)
  6. Lung Disorders
  7. ACE Inhibitors (>20% of pts)
  8. B-blockers in patients with COPD and asthma
    - Even eye drops can cause effects
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9
Q

What are the major causes of cough in children?

A
  1. Viral/bacterial respiratory infection
  2. Heart disease
  3. Foreign body aspiration
  4. Poor coordination of sucking and swallowing reflexes
  5. Esophageal motility disorders
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10
Q

What are symptoms and signs of a productive cough?

A

Wet or “chesty” cough

  • Expels secretions from the lower respiratory tract
  • Retention of secretions can cause impaired ventilation and decreases the lungs ability to resist infection
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11
Q

Patient presents with a productive cough and has been diagnosed with an anaerobic infection? Describe the secretions the patient may cough up.

A

Malodorous = foul-smelling

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12
Q

Patient coughs up yellow secretions. What is the possible cause?

A

yellow = inflammation (WBCs present)

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13
Q

Patient coughs up red/pink secretions. What is the possible cause?

A

hemoptysis - blood that initially came from lower respiratory tract

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14
Q

Patient coughs up clear secretions. What is the possible cause?

A

bronchitis

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15
Q

Describe the signs/symptoms of a patient who has a dry cough and what can cause this?

A
"Hacking" cough that serves no physiological purpose
Causes:
Viral respiratory tract infections
Atypical bacterial infections
GERD
Cardiac disease
Medications: ACE inhibitors
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16
Q

What are the concerning complications of a patient who has a persistent cough?

A

Exhaustion, insomnia, muscle pain, hoarseness, sweating, urinary incontinence
- Some may induce vomiting, cardiac dysrhythmias, syncope, stroke, rib fractures due to intensity

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17
Q

When should you refer a patient to a physician for a cough?

A

Child under 4 years old
Cough lasting > 7 days
Violent cough, night sweats - May be Pneumonia or TB
Coughing up blood or non-clear sputum
SOB - may sound like barking or whooping
Fever ≥ 103° in adults or ≥ 102° in children
Abdominal swelling
Unintentional weight loss
Hx of chronic lung disease
Foreign object aspiration
Suspected drug-induced cough
Cough is unresponsive/worsening with self-treatment

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18
Q

What are the top 3 causes of chronic cough in adults?

A
#1 UACS - Post nasal drip
#2 Asthma
#3 GERD
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19
Q

When should you recommend a patient use Hydrocodone for a cough? What should you counsel the patient on?

A

Antitussive = non-producitve cough
Adults who no history of substance abuse disorders (CII)
Children 6+ years old

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20
Q

What is the role of antitussives in cough treatment?

A

Control or eliminate cough by increasing the cough threshold for non-productive coughs

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21
Q

What is the role of protrussives in cough treatment?

A

Decrease sputum viscosity, increase sputum volume and facilitate its removal for productive coughs with thick mucous

22
Q

What age is safe for children to use cough drops?

A

> 6 years old according to the Academy of Pediatrics

23
Q

What are the guidelines for giving children honey to relieve chronic cough?

A

DO NOT USE UNDER AGE 1
1 to 6 y.o. = Give dark honey or corn syrup
> 6 y.o. = can use cough drops/honey products

24
Q

What can you recommend for a cough due to URI or chronic bronchitis?

A

ipratropium

25
Q

What can you recommend for postinfectious cough?

A
#1 Ipratropium
#2 Inhaled glucocorticoids
#3 Short course of Oral GCs if severe
#4 Central acting antitussive
26
Q

What products are not recommend for a cough due to a common cold?

A

Zinc

Combo antihistamine-decongestants (2nd gen)

27
Q

T/F: Codeine has been shown to provide significant benefit in reducing acute cough symptoms.

A

False; Dextromethorphan has been show while antihistamines and codeine have not show benefit

28
Q

Why should you recommend licorice as an herbal treatment for cough?

A

TRICK You shouldn’t!

- Due to Adverse Drug Reactions of CV effects and HYPOkalemic rhabdomyolysis

29
Q

Which alternative product should you avoid in diabetes for cough? Why?

A

Marshmallow; Induces hypoglycemia

30
Q

List the FDA-approved topical antitussives. How do they work?

A

Camphor and menthol; Pts inhale the vapors to stimulate the sensory nerve ending in the nose to create a sense of improved air flow
- Eucalyptus is NOT FDA-approved

31
Q

Guafenesin MOA + Side Effects

A

Expectorant
MOA: Loosens and thins lower respiratory tract secretions and makes minimally productive coughs more productive

SE: N/V, rash, diarrhea, headache

32
Q

Diphenhydramine MOA + Side Effects

A

1st Gen Antihistamine
- FDA approved antitussive

MOA: Acts of the respiratory centers in the medulla to increase the cough threshold

SE: Drowsiness, Disturbed coordination, dry mouth, blurred vision, urinary retention
- Paradoxical excitement/hyperactivity in younger children may occur

33
Q

Which patients should not receive diphenhydramine?

A
Narrow angle glaucoma
CVD
Asthma
HTN
Hyperthyroidism
34
Q

Benzonatate MOA + Side Effects

A

Rx only Antitussive

MOA: Local anesthetic effect on respiratory passages, lung and pleural stretch receptors

SE: sedation, HA, nausea, rash, dizziness, numbness of chest

Do not use in children under 10 y.o.

35
Q

Dextromethorphan MOA + Side Effects

A

Opioid-derived antitussive
MOA: acts on respiratory centers in the medulla to increase cough threshold

SE: dizziness, drowsiness, fatigue, drunk-like behavior with overdose

36
Q

Dextromethrophan is found to be _________ with codeine.

A

equipotent

37
Q

Hydrocodone MOA + Side Effects

A

CII Antitussive
MOA: Acts centrally on the respiratory center in the medulla to increase the cough threshold

SE: N/V, drowsiness and constipation

38
Q

Codeine MOA + Side Effects

A
CV Antitussive (OTC in some states, like IA)
MOA: Acts centrally on the respiratory center in the medulla to increase the cough threshold

SE: N/V, drowsiness and constipation

39
Q

Chlophendianol MOA + Side Effects

A

MOA: Antihistamine with antitussive, anesthetic and mild anticholinergic effects

SE: dizziness, drowsiness, fatigue

40
Q

Discuss the OTC product Coricidin HBP Cough and Cold.

A

“Triple C” - contains dextromethorphan + chlorpheniramine

- SE: May cause heart arrhythmias (chlorphen.)

41
Q

Which drugs have the fastest on-set for antitussive activity?

A

15 to 30 minutes = dextromethorphan, hydrocodone, codeine

42
Q

What medication history is important to ask about before recommending dextromethorphan?

A

MAOI use in the past 2 weeks: Fluoxetine, paroxetine

- Cause N/V, blurred vision, hallucinations or Serotonin syndrome

43
Q

Serotonin Syndrome Signs

A

HTN, Hyperthermia, Myoclonus, Mental status changes

44
Q

Dextromethorphan

A
  • opioid derived antitussive
  • no analgesic
  • no sedative
  • no respiratory depressant
  • no addictive properties at therapeutic doses
45
Q

MOA of dextromethorphan

A

Acts on respiratory centers in medulla to increase cough threshold

46
Q

ADR dextromethorphan

A
  • dizziness
  • drowsiness
  • fatigue
47
Q

Abuse of dextromethorphan

A
  • stupor/disorientation, euphoria, difficulty walking

- may cause seizures and be fatal

48
Q

T/f codeine antitussives are the gold standard

A

False! Used to be, but current evidence suggests otherwise

  • dextromethorphan preferred
49
Q

What is the only FDA approved non-prescription expectorant?

A

Guaifenesin (mucinex)

50
Q

Which expectorant should you always drink plenty of water with?

A

Guaifenesin

51
Q

Non-pharmacologic treatment of coughs

A
  • increase hydration best
  • warm fluids
  • hard candies & lozenges (>6 y/o)
  • honey (avoid <1 y/o)
  • cocoa
  • vaporizers & humidifiers (may soothe irritated airways and decrease cough, cool mist preferred)
52
Q

Treat post-infectious cough

A
  1. Inhaled ipratropium
  2. Inhaled glucocoritoids (GC)
  3. Short course of PO GC if severe
  4. Central acting antitussive