Corticosteroids (lec 24)

Question 1

Types of Corticosteroids?

Answer 1

Mineralocorticoids (Aldosterone)

Glucocorticoids (Cortisol)

Question 2

Mineralocorticoids regulated by?

Answer 2

Ang II and K+

Question 3

Glucocorticoids regulated by?

Answer 3

ACTH

stress released, nuclear receptors

Question 4

Glucocort Excess causes?

Answer 4

Cushing’s

Question 5

Cushings: caused by?

Answer 5

↑ ACTH via tumor -> ↑ cortisol

Exogenous glucocorts

Question 6

Cushings: signs/sxs?

Answer 6

moon face,
buffalo hump,
striae,
slow healing,
easy bruising,
think skin

Question 7

Adrenocortical insufficiency caused by?

Results in?

Answer 7

↓ or Φ corticosteroids from adrenal/pituitary dz:

Addison’s

Question 8

Addisons: signs/sxs?

Answer 8

weak,
weight loss,
hyperpigmentation,
hypoTN,
hypoglycemia,
poor stress response

Question 9

Addisonian Crisis is?

Sxs?

Answer 9

acute adrenal insuff

cir collapse,
dehyd/vomiting/hyperK+
FATAL