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Step 1 > Copy of Psychiatry - Sheet1 > Flashcards

Copy of Psychiatry - Sheet1 Flashcards

1
Q

Trifluoperazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

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2
Q

Fluphenazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

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3
Q

Haloperidol

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

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4
Q

Chlorpromazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

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5
Q

Thioridazine

A

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

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6
Q

Olanzapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gain
4) Fun Facts:

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7
Q

Clozapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Clozapine specific: weight gain, agranulocytosis and seizures.
4) Fun Facts: Must monitor WBC. Must watch clozapine clozely

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8
Q

Ziprasidone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Ziprasidone prolongs QT interval.

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9
Q

Quetiapine

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

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10
Q

Risperadone

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

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11
Q

Aripiprazole

A

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

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12
Q

Lithium

A

1) Use: Bipolar, SIADH
2) Class/MOA: Not established. Related to phosphoinositol cascade (?)
3) Side effects/ADEs: Movement, Nephrogenic DI, hypOthyroidism, Pregnancy (LMNOP)
4) Fun Facts: May cause fetal cardiac defects, excreted by kidneys

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13
Q

Buspirone

A

1) Use: Generalized anziety disorder
2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines

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14
Q

Fluoxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

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15
Q

Paroxetine

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

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16
Q

Sertraline

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

17
Q

Citalopram

A

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

18
Q

Venlafaxine

A

1) Use: Depression. Venlafaxine also in GAD, panic disorders.
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake
3) Side effects/ADEs:Increased BP

19
Q

Duloxetine

A

1) Use: Depression, diabetic peripheral neuropathy.
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake (greater effect on NE than other SNRI-venlafaxine). Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
3) Side effects/ADEs:Increased BP

20
Q

Amitriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 3rd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Third generation TCAs have more anticholinergic side effects

21
Q

Nortriptyline

A

1) Use: Major depression, fibromyalgia
2) Class/MOA: 2nd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Second generation TCAs have fewer anticholinergic side effects

22
Q

Imipramine

A

1) Use: Major depression, fibromyalgia, bedwetting
2) Class/MOA: Tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: use for bedwetting is imipramine specific.

23
Q

Desipramine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Less sedating, higher seizure threshold. .

24
Q

Clomipramine

A

1) Use: Major depression, fibromyalgia. First line OCD.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

25
Q

Doxepin

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

26
Q

Amoxapine

A

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

27
Q

Tranylcypromine

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

28
Q

Phenelzine

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

29
Q

Isocarboxazid

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

30
Q

Selegiline

A

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John’s wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

31
Q

Bupropion

A

1) Use: Smoking cessation. Depression
2) Class/MOA: Atypical antidepressant. Increase NE/dopamine via unknown mechanism
3) Side effects/ADEs: Toxicity: tachycardia, insomnia, headache, seizures in bulimics
4) Fun Facts: No sexual side effects

32
Q

Mirtazapine

A

1) Use: Depression.
2) Class/MOA: Atypical antidepressant. Alpha2 antagonist (increases NE and serotonin), potent 5-HT2 and 5-HT3 antagonist
3) Side effects/ADEs: Toxicity: sedation, increase in appetite, weight gain, dry mouth
4) Fun Facts: May be used in anorexics due to side effect of weight gain

33
Q

Maprotiline

A

1) Use: Depression.
2) Class/MOA: Blocks NE reuptake.
3) Side effects/ADEs: Orthostatic hypotension, sedation

34
Q

Trazodone

A

1) Use: Depression (at high doses). Insomina primarily.
2) Class/MOA: Atypical antidepression
3) Side effects/ADEs: Sedation, nausea, priapism, postural hypotension
4) Fun Facts: Called trazoBONE due to male specific side effect

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