COPD treatment Flashcards

1
Q

Name some pharmacological therapy for COPD

A

-bronchodilators
-corticosteroids
-oxygen

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2
Q

Name some non pharmacological therapy of COPD

A

-self care
-pulmonary rehabilitation
-surgery
-dietary
-NIV- usually BiPAP ( acute exacerbations
-end of life planning

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3
Q

Descibe what patients can do to help smoking cessation

A

-group therapy
-online support
-Nicotine replacement therapy (NRT)
-stop smoking medication

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4
Q

Describe NRT

A

-skin patches
-gum
-tablets, strips, losenges
-nasal/mouth spray
-e- cigarettes

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5
Q

Give some side effects of NRT

A

-skin irritation with patches
-irritation of nose, throat or eyes with nasal spray
-distrubed sleep
-upset stomach
-dizziness/headaches

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6
Q

Name some stop smoking medications

A

zyban- bupropion
-champix- vareicline

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7
Q

What are bronchodilators?

A

-relax smooth muscles around bronchioles
-maximise bronchodilation
-allow easier airflow

Two main groups used in COPD:
-Beta2 agonist - inhlaed
-antimuscarinics- inhaled

can be short or long acting

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8
Q

Why do we give bronchodilators if airway obstruction is irreversible?

A

bronchodilators help to reduce lung hyperinflation which improves resp muscle function and therfore better overal function

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9
Q

What does the bronchodilator anticholinergics do?

A

-atrovent ipratropium bromide
-spirivia (tiotropium)
-block parasympathetic maintenance of bronchial tone
-receptors precent in all airways but more prevelant in central airways

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10
Q

What does the bronchodilator Beta2 agonists do?

A

Ventolin- sambutamol
-relax airway smooth muscle
-receptors more prevelant in peripheral airway

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11
Q

What does it mean when Beta2 agonists and antichollenergic drugs act synergistically?

A

-act on different receptors
-act on different locations
-different modes of action
-combined effect on bronchodilator pathways

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12
Q

What are the effects of corticosteroids?

A

-used to reduce inflam in COPD (inhaled steroids alter genes within leukocyte nuclei and so damp down inflam)
-usually given in a combination with beta2 agonists or anticholenergic drugs
-reduced exacerbation rates
-improves health statue anad spiro
-but also has a greater risk of pneumonia

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13
Q

Name some combination inhalers

A

-steroid plus long acting beta2 agonist:
-symbicort, fostair, revlar

long acting beta 2 agonist plus long acting muscarinic antagonist:
-anoro

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14
Q

What is triple therapy in patients with COPD?

A

-combining LAMA, LABA and ICS

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15
Q

what does SABA stand for?

A

short acting B2 agonist

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16
Q

What does LABA stand for?

A

long acting B2 agonist

17
Q

What does SAMA stand for?

A

short acting antimuscarinic agent

18
Q

What does LAMA stand for?

A

long acting antimuscarinic agent

19
Q

Name some other drug therapys for COPD

A

-antimicrobial- exacerbations and recurrent chest infections

-Mucolytics-reduce mucous production

-oxygen
-may increase QOL and excersise tolerance
-Beware of CO2 retention
-type II resp failure
-long term o2 therapy - min 15hrs a day

-treatment for anxiety and or depression

20
Q

briefly describe the types of resp failure

A

type 1- lung failure
-gas exchange failure mainfested by hypoxaemia

type 2- pump failure
-ventilatory failure manifested by hypercapnia

21
Q

Describe type 1 resp failure

A

-failure of oxygenation
-V/Q mismatch
-shunt
-diffusion impairment
-alveolar hypoventilation

22
Q

Describe type 2 resp failure

A

-failure of ventilation
-failure of resp muscles, increased work of breathing or resp control
-increased production of CO2
-increased dead space
-shunt

23
Q

Why does supplemental O2 cause CO2 retention?

A

-in healthy subjects increases in CO2 increases the drive to breath

-patients with COPD develop a reduced response to CO2 over time and so O2 levels are the main stimulus to breath ( hypoxic drive)

additional O2 reduces hypoxic drive and patients will hypoventilate

-This causes accumulation of CO2 in the blood and results in hypercapnia and results in respiratory acidosis

-PH od 6.8 or less is fatal

24
Q

what is involved in pulmonary rehab?

A

-weekly group class with education and excersise
-excersise-increases muscle strength and fitness to reduce breathlessness

education- nutrition, living with COPD, finanical claim advice, COPD medication, treating exacerbations

25
Q

Name some surgical treatments of COPD

A

-lung volume reduction surgery (LVRS)
-bullectomy
-lobectomy
-pneumonectomy
-transplant

26
Q

What can be done to improve COPD management?

A

-accurate early diagnosis
-smoking cessation
-vaccinations
-inhaler technique
-functionality and symptom assessment
-improving self management skills
-education
-appropriate refferals( O2 assessment, pulmonary rehabilitation, nutrition)