COPD Flashcards
0
Q
What disease process occurs in chronic bronchitis?
A
Neutrophilic inflamm
Mucus hypersecretion
Smooth muscle spasm and hypertrophy
1
Q
Why is tiotropium superior to ipratropium?
A
Functional selective due to longer half life at M3
Doesn’t block M2
2
Q
What is the disease process in emphysema?
A
Alveolar destruction
Impaired gas exchange
Loss of bronchial support
3
Q
Which of the two forms of COPD is reversible?
A
Chronic bronchitis
4
Q
How is alveolar destruction brought about in emphysema?
A
Increased levels of proteases due to smoking
Decreased levels of anti-proteases due to genes
5
Q
How does someone with COPD present clinically?
A
Smoker Non-atopic Daily productive cough Progressive SoB Frequent infective exacerbations CB- wheeze E - reduced breath sounds
6
Q
What are the main types of emphysema?
A
Centriacinar
Panacinar
