control of airway cells Flashcards

1
Q

hormonal

A

adrenaline from the adrenal gland

relaxes airway

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2
Q

NO control of airways

A

only humans
speeds up the movement of cilia
vasorelaxant - dilates bv and airways

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3
Q

SNS control

A

done by animals and not people
causes release of adrenaline
opens the airways

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4
Q

PNS control

A

signal from the brainstem down the vagus nerve causes constriction of the airway
it is a cholinergic pathway
motor pathway
uses muscarinic receptors
neurotransmitter is acetyl choline
cause mucous to enter airway = slippery = easier to cough substances out

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5
Q

inflammatory cells in airways

A

eosinophils, neutrophils, macrophages, mast cells, T lymphocytes, structural cells - can take on inflammatory component
these cells produce >1 mediator
each mediator does >1 thing

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6
Q

what do mast cells make

A
histamine 
adenosine 
prostaglandins 
leukotrienes 
PAF (platelet activating factor) 
cytokines
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7
Q

inflammatory mediators

A
cytokines 
chemokines
histamine 
serotonin 
adenosine 
prostaglandin 
leukotrienes
thromboxane
PAF 
endothelin
GF 
proteinases
reactive gas species
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8
Q

actions of mediators

A
SM contraction/relaxation 
secretion - mucin, water 
plasma exudation 
neural modulation 
chemotaxis
remodelling
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9
Q

histamine

A
contract airway sm 
relax bv sm 
plasma exudation 
mediate neuronal function 
secrete mucin
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