Contraindications

Question 1

Disulfiram

Answer 1

Indiv with liver failure or acute hepatitis

Question 2

Naltrexone

Answer 2

Indiv with liver failure or acute hepatitis

Question 3

Ribavirin (HCV)

Answer 3

Pregnant women

Question 4

Pegylated (Peg) Interferon

Answer 4

Hepatic decompensation
 Autoimmune disease
Hx cardiac arrhythmia
Severe depression
 Pregnancy

Question 5

Simeprevir

Answer 5

Renal dysfunction

Question 6

H2 Receptor Antagonists

Answer 6

Considered safe in pregnancy but can cross placenta so use caution

Question 7

Cimetidine

Answer 7

Significant drug interactions

(inhibits CYP1A2, CYP2C9, CYP2D6, CYP3A4)…clinical adverse effects with warfarin, phenytoin etc

Question 8

Proton Pump Inhibitors (PPI)

Answer 8

Pregnancy- cross placenta & elim in breast milk

Caution- liver dz pts

Question 9

Sucralfate

Answer 9

Do not co-damin with antacids

Question 10

Bismuth Subsalicylate

Answer 10

Do NOT use in children (because salicylic acid)

Question 11

Misoprostol

Answer 11

Pregnancy → can induce uterine contractions

Question 12

Stimulant Laxative

Answer 12

Cramps, colic, nausea, vomiting, other symptoms of appendicitis, undiagnosed abdominal pain

Question 13

Lubiprostone

Answer 13

Pregnancy- risk to fetus

Question 14

Linaclotide

Answer 14

Pediatric patients because of reports of ↑ mortality in juvenile mice from dehydration

Question 15

Mg(OH)2

Answer 15

CAUTION in pts with Renal insufficiency

↑ risk of hypermsgnesemia

Question 16

Loperamide

Answer 16

Avoid in pts with ulcerative colitis or acute bacillary or amoebic dysentery → risk of toxic megacolon because fragile mucosa