Contraception Flashcards
Describe the mechanism of combined oral contraceptives
Estrogen > Suppress FSH > No folliculogenesis > prevents ovulation
Progesterone > Thickens cervical mucus, impairs tubal motility + peristalsis, endometrial decidualization and eventual atrophy
List common contraindications for COCs
- Age 35 + Tobacco Use
- Risk factors for CAD
- HTN
- Hx VTE, Stroke, Thrombogenic mutations
- Valvular heart disease
- Breast Cancer
- Liver disease
- Migraine w/ Aura
- Roux-en-Y (no PO contraception due to impaired absorption)
- Pt using meds that induce hepatic enzymes (OCPs not as effective due to increased metabolism)
Which progesterones are considered to have low androgenicity? medium androgenicity? high androgenicity?
Low: Norgestimate, dropirenone, desogestrel
Medium: Norethindrone
High: Norgestrel, Levonorgestrel
What is the failure rate for OCPs with “typical use”?
7-10%
What is the failure rate for POPs with “typical use”?
9%
What is the failure rate for DMPA with “typical use”
6%
What is the mechanism for DMPA?
Suppresses gonadotropins, thickens cervical mucus, decreases tubal motility
What is the BLACK BOX warning for DMPA?
Loss of 5% of bone mineral density with 5 years of use, completely reversible after5 years if used < 2 years
*Conflicting data on fracture risk
What is the failure rate for LARCs?
All methods effective with failure rate <1%
What is the failure rate for Nexplanon?
0.05%
Describe key points when counseling patients about Nexplanon/”The implant”
- 68 mg Etonogestrel*
- Effective for 3 years
- Failure rate 0.05%
- 1-2% risk of insertion/removal complications
- 10% discontinue for AUB
- Typically 10 days of spotting for every 90 days
**Contraindication: Current breast cancer
What is the mechanism of action of Nexplanon?
Suppresses ovulation, thickens cervical mucus, decreased tubal motility
What is the mechanism for LNG-IUD?
Decreased sperm migration due to thickened cervical mucus viscosity
Describe key points when counseling patients about LNG-IUD
- Effective 3-5 years pending type
- Failure rate 0.2% in first year
- Risk of expulsion 2-10% in first year
- Risk of perforation = 1.4 per 1,000 insertions
- Side effects = AUB, pain, N/V, HA, mood changes, ovarian cyst formation
What is the mechanism of Cu-IUD?
Inflammatory! Decreased sperm migration, ovum transport, ovum destruction